National Deuteration Facility

  

National Deuteration Facility 3
The National Deuteration Facility (NDF) offers the facilities, staff and expertise to produce molecules in which all or part of the molecular hydrogen is in the form of deuterium (2H or D). This enables complex investigations of the relationship between the structure of molecules and their function using neutron scattering, Nuclear Magnetic Resonance and other types of spectroscopy. 
 
The NDF is a unique facility offering molecular deuteration using both in vivo biodeuteration or chemical deuteration techniques. It produces deuterated proteins, biopolymers, nucleic acids and synthesised small organic molecules such as lipids, phospholipids, sugars, surfactants, aliphatic hydrocarbons and aromatic, heterocyclic compounds. Double and triple labelling of proteins with both deuterium and the stable isotopes carbon-13 and/or nitrogen-15, are also available.
 
The nationally recognised facility is NCRIS funded and the only one of its kind in the Southern Hemisphere.
 
PDF icon Factsheet


More information

 


 

Applications

 

  • Medicine, health, pharmaceutical and drug delivery research
  • Energy and gas storage materials
  • Biopolymers and biotechnology
  • Thin film nanotech devices
  • Food-lipid digestion
  • Molecular electronics
  • Structural biology
  • Communications and electronics
  • Friction modifiers studies.

 


 

Capabilities

 

The NDF can provide the following types of deuterated molecules:

  • Saturated fatty acids, alcohols, bromides, amines, aldehydes, thiols, alkanes
  • Partial and perdeuterated recombinant proteins
  • Saturated diacids and bifunctional surface active molecules
  • Double and triple labelled recombinant proteins
  • Deuterated silanes
  • Unsaturated fatty acids (e.g. oleic acid)
  • Membrane protein detergents (e.g. DDM and OG)
  • Glyme and glycol ethers
  • Deuterated surfactants including ionic and non-ionic
  • Lipids including glycerides; phospholipids (e.g. DOPC and POPC); and selective deuteration of lipids (head deuterated, tail deuterated and fully deuterated)
  • Aromatics and heterocyclics for MOFs
  • Compounds for organic light emitting diodes
  • Compounds for solar cells Electrolytes for batteries
  • Selective deuteration of small molecules sugars
  • Biopolymers – cellulose, chitosan, chitin, PHAs
  • PE77 reference material for isotope-ratio mass spectrometry

 


 

Facilities

 

Ten laboratories and instruments including Nuclear Magnetic Resonance Spectroscopy (NMR) and Liquid Chromatography - Mass Spectroscopy (LCMS) and Fourier Transform Infrared (FTIR) Spectroscopy.

 


 

Contact us

 

For enquiries please contact our User Office on user.office@ansto.gov.au, call +61 2 9717 9111 or ndf-enquiries@ansto.gov.au.

 


 

Access

 

Access to the NDF is merit-based through a proposal program via the Neutron User Portal. Accelerated or commercial access can be provided subject to services charges.