Dr Paul Pellegrini

Radiochemist
Phone - +61 2 9717 9708
   
Pellegrini Paul research profile photo

Profile

Role at ANSTO


Paul's contributions include the production of radionuclides of interest for ANSTO LifeSciences and its collaborating partners. He also labels molecules with radiometals for nuclear medicinal applications.


Background


Before joining LifeSciences in 2006, Paul had performed contract work for ANSTO's radionuclide development program from 2003. He has experience in the production of 177Lu from reactor irradiated targets, as well as other radionuclides produced via reactors, cyclotrons and generators.


Research interests and areas of expertise


Paul's areas of interest are in the research and development of radiometals with potential for PET and SPECT diagnostics and therapeutic nuclear medicine applications.

Paul has worked on the LifeSciences Radionuclide generator programme, including the PET relevant 68Ge/68Ga generator.


Qualifications & Achievements

 

Before receiving his PhD in radiopharmaceutical development from the University of Western Sydney (UWS) in collaboration with ANSTO, Paul also completed a BSc majoring in Chemistry and an MSc in Coordination Chemistry, also at UWS. Most recently, Paul attended the World Nuclear University's first School on Radioisotopes, held in Seoul in 2010.

 

 

 

Selected publications

Oehlke, E., Lengkeek, N., Le, V. S., Pellegrini, P., Greguric I., Weiner, R. The role of additives in moderating the influence of Fe[III] and Cu[II] on the radiochenical yield of [68Ga(DOTATATE)]. Applied Radiation and Isotopes, 107, 13–16 (2016). doi: 10.1016/j.apradiso.2015.09.008

 

Chan, C. Y., Pellegrini, P., Greguric, I., Barnard, P. J. Rhenium and technetium tricarbonyl complexes of N-heterocyclic carbene ligands. Inorganic Chemistry, 53(20), 10862-73 (2014). doi: 10.1021/ic500917s

 

Tan, K., Pellegrini, P., Skelton, B.W., Hogon, C.F., Greguric, I., Barnard, P. Triamidetriamine bearing macrobicyclic and macrotricyclic ligands: potential applications in the development of copper-64 radiopharmaceuticals. Inorganic Chemistry, 53(1), 468–477 (2014). doi: 10.1021/ic4024508

 

Pellegrini, P. A., Howell, N. R., Shepherd, R. K., Lengkeek, N. A., Oehlke, E., Katsifis, A. G., Greguric, I. Synthesis and radiolabelling of DOTA-linked glutamine analogues with 67,68Ga as markers for increased glutamine metabolism in tumour cells. Molecules, 18(6), 7160-7178 (2013). doi: 10.3390/molecules18067160

 

Oehlke, E., So, L. V., Lengkeek, N. A., Pellegrini, P., Jackson, T., Greguric, I., Weiner, R. Influence of metal ions on the 68Ga-labeling of DOTATATE Applied Radiation and Isotopes, 82, 232–238 (2013). doi: 10.1016/j.apradiso.2013.08.010

 

Pellegrini, P. A., Howell, N. R., Shepherd, R. K., Lengkeek, N. A., Oehlke, E., Katsifis, A. G., Greguric, I. Synthesis and radiolabelling of DOTA-linked glutamine analogues with 67,68Ga as markers for increased glutamine metabolism in tumour cells. Molecules, 18(6), 7160-7178 (2013). doi: 10.3390/molecules18067160

 

Le, V.S., Nguyen, C. D., Pellegrini, P., Bui, V. C. Polymeric titanium oxychloride sorbent for 188W/188Re nuclide pair separation. Separation Science and Technology, 44(5), 1074-1098. (2009)

 

Le, V. S., Howse, J., Zaw, M., Pellegrini, P., Katsifis, A., Greguric, I.,Weiner, R. Alternative method for 64Cu radioisotope production. Applied Radiation and Isotopes, 67(7-8), 1324-1331. (2009)

 

Le, V. S., Morcos, N., Zaw, M., Pellegrini, P., Greguric, I. Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation – Part I. Journal of Radioanalytical and Nuclear Chemistry, 277(3), 663–673. (2008)

 

Le., V.S., Morcos, N., Zaw, M., Pellegrini, P., Greguric, I., Nevissi, A. Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation - Part II. The conventional column chromatographic separation combined with HPLC for high purity, no-carrier added 177Lu radioisotope production. Journal of Radioanalytical and Nuclear Chemistry, 277(3), 675–683. (2008)

 

Le, V.S., Pellegrini, P., Katsifis A., Howse J., Greguric I., Radiochemical separation and quality assessment for the 68Zn target based 64Cu radioisotope production. Journal of Radioanalytical and Nuclear Chemistry, 277(2), 451–466. (2008)