Dr Ivan Greguric
Staff Profile
Role at ANSTO
Directing radiochemistry research, Ivan also manages the radiochemistry platform in ANSTO LifeSciences. Ivan's main research activities have been in the development of PET and SPECT benzamides and amino acid compounds as radiopharmaceuticals for cancer.
Background
Before accepting a position with ANSTO's Radiopharmaceutical Research Institute as a post doctoral research fellow in 2000, Ivan worked at Orica and Schering Plough Animal Health.
During Ivan’s time as a post-doc fellow, he worked on thallium-201 targetry and separation, then moved to synthesis and radiolabelling of molecules for imaging cancer and the brain. In 2004 he was appointed as a radiopharmaceutical chemist in the Radiopharmaceutical Research Institute and continued with the development of diagnosis and therapeutic radiopharmaceuticals and was involved with the 176Lu, 177Lu, and 64Cu programs.
In 2006 Ivan was appointed as the chemistry group leader and managed radiochemistry activities in the CRCBID. In 2010 Ivan was appointed the Head of Radiochemistry in the newly formed ANSTO Lifesciences division.
Research interests and areas of expertise
Ivan’s current research interests include the development of ligands for the complexation of radiometals (89Zr, 68Ga, 64Cu, 177Lu) and the development of reagents, processes and radio-synthons for smarter and faster 18F chemistry, using micro and macrofluidic platforms.
His expertise lies in inorganic and organic chemistry, radiolabelling, labelling of proteins/peptides antibodies, amino acids and small molecules, isotope separation, HPLC, PET, SPECT, radioHPLC using 18F, 177Lu, 123I, 125I, 124I, 99mTc, 64Cu radionuclides.
Qualifications & Achievements
Head of Radiochemistry (2010-Current)
Chemistry Group leader (2006-2010)
Project Manager, CRC imaging (2006-Current)
PhD in Synthetic Chemistry, UWS Macarthur (2000)
Publications
Wyatt, A. R., Yerburyn J. J., Berghofer P., Greguric, I., Katsifis, A., Dobson, C. M., Wilson, M. R. Clusterin facilitates in vivo clearance of extracellular misfolded proteins. Cellular and molecular life sciences, 68(23), 3919-31. (2011)
Bourdier, T., Shepherd, R., Berghofer, P., Jackson, T., Fookes, C. J., Denoyer, D., Dorow, D., Greguric, I., Gregoire, M-C., Hicks, R. J., Katsifis, A. Radiosynthesis and biological evaluation of l- and d-S-(3-[(18)F]Fluoropropyl)homocysteine for tumor imaging using Positron Emission Tomography. Journal of Medicinal Chemistry, 54(6), 1860-70. (2011)
Denoyer, D., Potdevin, T., Roselt, P., Neels, O., Kirby, L., Greguric, I., Katsifis, A., Hicks, R. Improved detection of regional melanoma metastasis using 18F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide, a melanin-specific PET probe, by perilesional administration. Journal of Nuclear Medicine. 52(1), 115-22. (2011)
Katsifis, A., Loc'h, C., Henderson, D., Bourdier, T., Pham, T., Greguric, I., Lam, P., Callaghan, P., Mattner, F., Eberl, D., Fulham, M. A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [(18)F]PBR102 and [(18)F]PBR111, in rat and primate plasma. Nuclear Medicine and Biology, 38(1), 137-48. (2011)
Greguric, I., Taylor, S. R., Denoyer, D., Ballantyne, P., Berghofer, P., Roselt, P., Pham, T. Q., Mattner, F., Bourdier, T., Neels, O. C., Dorow, D. S., Loc'h, C., Hicks, R. J., Katsifis, A. Discovery of [(18)F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: a melanoma positron emission tomography imaging radiotracer with high tumor to body contrast ratio and rapid renal clearance. Journal of medicinal chemistry, 52(17), 5299-5302. (2009)
Fookes, C. J., Pham, T. Q., Mattner, F., Greguric, I., Loc'h, C., Liu, X., Berghofer, P., Shepherd, R., Gregoire, M-C., Katsifis, A. Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography. Journal of medicinal chemistry, 51(13), 3700-12. (2008)
Le, V. So., Morcos, N., Zaw, M., Pellegrini, P., Greguric, I. Alternative chromatographic processes for no-carrier added 177Lu radioisotope separation. Journal of Radioanalytical and Nuclear Chemistry, 277(3), 663-673. (2008)