Mr Nicholas Howell
Cell Biology Professional Officer
ANSTO Life Sciences
Staff Profile
Role at ANSTO
Nicholas works in the Bioanalytics group under Prof. Richard Banati providing expertise and support for the in vitro evaluation of novel compounds, peptides, proteins and particles. He also provides expertise and support for the analytical biology requirements of ANSTO LifeSciences and its collaborators in radiological and nuclear methodologies for applications.
Background
Graduating from Macquarie University with BSc in Biotechnology, Nicholas has been working at ANSTO as a biologist for 5 years.
Areas of expertise and Research interests
Nicholas has expertise and interest in the application of radiological and nuclear techniques to the analysis of biological systems and structures. Other areas of expertise include in vitro pharmacology, RT-qPCR, immunohistochemistry, cell culture.
Publications
Szabo, A. M., Howell, N. R., Pellegrini, P., Greguric, I., Katsifis, A. Development and validation of competition binding assays for affinity to the extracellular matrix receptors, αvβ3 and αIIbβ3 integrin. Analytical Biochemistry, 423(1) 70-77. (2012)
Peyronneau, M., Mattner, F., Howell, N., Jiang, C., Pellegrini, P., Greguric, I., Loch, C., Katsifis, A. Metabolism of CLINDE, a peripheral benzodiazepine receptor SPECT ligand. European Journal of Nuclear Medicine and Molecular Imaging, 37(2), S242. (2010)
Mattner, F., Pham, T., Berghofer, P., Howell, N., Bourdier, T., Rahardjo, G., Kench, P. L., Zahra, D., Gregoire, M-C., Katsifis, A. Pharmacological evaluation of the Peripheral Benzodiazepine Receptor radioligand [123I]-CLINDE in a breast tumour model. 57th Annual Meeting of the Society of Nuclear Medicine, 5th – 9th June, Salt Lake City, UT, USA. (2010)
Mattner, F., Berghofer, P., Shepherd, R., Howell, N., Pham, T., Bourdier, T., Ballantyne, P., Katsifis, A. Ex vivo pharmacological evaluation of the Peripheral Benzodiazepine Receptor radioligand [123I]CLINDE in animal tumour model. 38th Annual Meeting of the Australia and New Zealand Society of Nuclear Medicine, 1st – 6th May, Gold Coast, Australia. (2008)