Dr Tien Pham
Radiochemistry Team Leader, Lucas Heights
ANSTO Life Sciences
Staff Profile
Role at ANSTO
Tien leads research tasks in the investigation of novel approaches to the synthetic incorporation of PET and SPECT radioisotopes onto small molecules, peptides and proteins.
Background
After completing his PhD in organic chemistry at the University of Wollongong in 2003, Tien accepted a position as a Post Doc at ANSTO. He then continued on as a research scientist. In both roles Tien was responsible for the synthesis and radiolabelling of small molecules, with 18F, 123I, 125I and 99mTc targeting cancer and neurodegenerative diseases. Tien is currently the radiochemistry task leader in ANSTO Lifesciences.
Expertise
Tien’s areas of expertise include organic chemistry, medicinal chemistry, radiochemistry, radiolabelling small molecules proteins/peptides, HPLC, PET, SPECT, 18F, 123I, 124I, 125I, 99mTc, 11C.
Qualifications & Achievements
- PhD in Organic Chemistry, at the University of Wollongong (2003)
- BSc (Hons) in Medicinal Chemistry (1998)
- Tien is a member of the Society of Radiopharmaceutical Science.
Publications
Bourdier, T., Pham, T. Q., Henderson, D., Jackson, T., Lam, P., Izard, M., Katsifis, A. Automated radiosynthesis of [(18)F]PBR111 and [(18)F]PBR102 using the Tracerlab FX(FN) and Tracerlab MX(FDG) module for imaging the peripheral benzodiazepine receptor with PET. Applied radiation and isotopes, 70(1), 176-183. (2012)
Katsifis, A., Loc'h, C., Henderson, D., Bourdier, T., Pham, T., Greguric, I., Lam, P., Callaghan, P., Mattner, F., Eberl, D., Fulham, M. A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [18F]PBR102 and [18F]PBR111, in rat and primate plasma. Nuclear Medicine and Biology, 38(1), 137-148. (2011)
Greguric, I., Taylor, S. R., Denoyer, D., Ballantyne, P., Berghofer, P., Roselt, P., Pham, T. Q., Mattner, F., Bourdier, T., Neels, O. C., Dorow, D. S., Loc'h, C., Hicks, R. J., Katsifis, A. Discovery of [(18)F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: a melanoma positron emission tomography imaging radiotracer with high tumor to body contrast ratio and rapid renal clearance. Journal of medicinal chemistry, 52(17), 5299-5302. (2009)
Fookes, C. J., Pham, T. Q., Mattner, F., Greguric, I., Loc'h, C., Liu, X., Berghofer, P., Shepherd, R., Gregoire, M-C., Katsifis, A. Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography. Journal of medicinal chemistry, 51(13), 3700-12. (2008)
Greguric, I., Pham, T. Q., Liu, X., Katsifis, A. Nicotinamide Derivatives for imaging and therapy of melanoma. Provisional Patent No: 2008901989, 2008.
Pham, T. Q., Berghofer, P., Liu, X., Greguric, I., Dikic, B., Ballantyne, P., Mattner, F., Nguyen, V., Loc'h, C., Katsifis, A. Preparation and biologic evaluation of a novel radioiodinated benzylpiperazine, 123I-MEL037, for malignant melanoma. Journal of nuclear medicine. 48(8), 1348-56. (2007)
Pham, T. Q., Greguric, I., Liu, X., Berghofer, P., Ballantyne, P., Chapman, J., Mattner, F., Dikic, B., Jackson, T., Loc'h, C., Katsifis, A. Synthesis and evaluation of novel radioiodinated benzamides for malignant melanoma. Journal of medicinal chemistry, 50(15), 3561-72. (2007)
Katsifis, A., Fookes, C. J. R., Pham, T. Q., Greguric. I., Mattner, F. Fluorinated ligands for targeting peripheral benzodiazepine receptors. Patent No: 2006904617, 2006.