Dr Andrew Whitten

Post-doctoral research fellow

Phone +61 (0)2 9717 3582
Email Andrew.Whitten@ansto.gov.au

Dr Andrew Whitten's research is concerned with small-angle scattering experiments aimed at studying how the activities of proteins are regulated via interactions with ligands and other proteins. This research is conducted in collaboration with Prof. Jill Trewhella in the School of Molecular and Microbial Biosciences at the University of Sydney, and the Characterisation of Biomolecules research project at ANSTO.

His expertise includes small-angle scattering, charge-density analysis, quantum chemistry and single-crystal diffraction

Andrew completed both honours and a Ph.D. under the supervision of Prof. Mark Spackman at the University of New England. The work mainly focused on the electric properties of molecules in crystals from accurate X-ray diffraction data and also from theoretical calculations.

Qualifications and achievements

• Ph.D. in Chemistry, University of New England (2005)

Key Publications

A. E. Whitten, C. M. Jeffries, S. P. Harris, J. Trewhella, Cardiac myosin-binding protein C decorates F-actin: Implications for cardiac function, Proc. Natl. Acad. Sci. U.S.A. 105, 18360-18365 (2008).

A. E. Whitten, S. Cai, J. Trewhella, MULCh: ModULes for the analysis of small-angle neutron Contrast variation data from biomolecular assemblies, J. Appl. Crystallogr. 41, 222-226 (2008).

D. Comoletti, A. Grishaev, A. E. Whitten, I. Tsignelny, P. Taylor, J. Trewhella, Synaptic arrangement of the Neuroligin/β-Neurexin complex revealed by X-ray and neutron scattering, Structure. 15, 693-705 (2007).

A. E. Whitten, D. A. Jacques, B. Hammouda, T. Hanley, G. F. King, J. M. Guss, J. Trewhella, D. B. Langley, The structure of the KinA-Sda complex suggests an allosteric mechanism of histidine kinase inhibition, J. Mol. Biol. 368, 407-420 (2007).

A. E. Whitten, M. A. Spackman, Anisotropic displacement parameters for H atoms using an ONIOM approach, Acta Crystallogr. B62, 875-888 (2006).

A. E. Whitten, P. Turner, W. T. Klooster, R. O. Piltz, M. A. Spackman, Reassessment of large dipole moment enhancements in crystals: A detailed experimental and theoretical charge density analysis of 2-methyl-4-nitroaniline, J. Phys. Chem. A 110, 8763-8776 (2006).

A. E. Whitten, C. J. Radford, J. J. McKinnon, M. A. Spackman, Dipole and quadrupole moments of molecules in crystals: A novel approach based on integration over Hirshfeld surfaces, J. Chem. Phys., 124, 074106 (2006).

A. E. Whitten, B. Dittrich, M. A. Spackman, P. Turner, T. C. Brown, Charge density analysis of two polymorphs of antimony(III) oxide, Dalton Trans. 1, 23-29 (2004).

G. V. Gibbs, A. E. Whitten, M. A. Spackman, M. Stimpfl, R. T. Downs, M. Carducci, An exploration of theoretical and experimental electron density distributions and SiO bonded interactions for the silica polymorph coesite, J. Phys. Chem. B 107, 12996-13006 (2003).