International Small-Angle Scattering Conference

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(1630 - 1800)

Welcome Reception

Parkside Foyer, SCEC

A1: Complex

Fluids 1

Chair: John White

B1: Structural Biology 1

Chair: Naoto Yagi

C1: Time

Resolved 1

Chair: Jan Skov Pedersen

D1: Porous Materials

Chair: Heinz Amenitsch

A2:Polymers 1

Chair: Kevin Jack

Kathryn Krycka
Magnetic Core-Shell Morphology of Structurally Uniform Magnetite Nanoparticles
Chair: Dale Schaefer

A3: Networks
Chair: Tsang-Lang Lin

B3: Membranes 1
Chair: Paul Butler

C3: Magnetic Materials
Chair: Kathryn Krycka

A4: Surfaces 1
Chair: Thomas Arnold

Cy Jeffries
Insight, discovery and new directions: small-angle scattering
and cardiac myosin binding protein c
Chair: Sung-Min Choi

A5: Polymers 2
Chair: Mitsuhiro Shibayama

 B5:Membranes 2
Chair: Lise Arleth

C5: Time
Resolved 2
Chair: Hideki Seto

Yuya Shinohara
X-ray Photon Correlation Spectroscopy of Filled Rubber
Chair: Aldo Felix Craievich

A6: Liquid
Crystals 1
Chair: Liliana De Campo

 B6: Structural Biology 4
Chair: Matthew Wilce

C6: Contrast Methods 1
Chair: Peter Holden

A7: Surfaces 2
Chair: Yachin Cohen

Tomotaka Oroguchi
Protein dynamics investigated by small angle X-ray solution scattering and molecular dynamics simulations
Chair: C.G.(Kees) De Kruif

A8: Complex
Fluids 2
Chair: Nick Terrill

 B8: Polymers 3
Chair: Robert Knott

C8: Applications and Technology 2
Chair: Bridget Ingham

A9: Liquid
Crystals 2
Chair: Peter Lindner

Lise Arleth, University of Copenhagen Denmark

Prof. Lise Arleth obtained her PhD in Biophysics at Risø National Laboratory and The Royal Danish Veterinary and Agricultural University in 2002 under prof. Jan Skov Pedersen. During her early career she has performed research with Prof. Thomas Zemb at CEA Saclay in France and with Prof. Stjepan Marcelja at ANU, Australia.

After a Post Doctoral stay with Prof. Rex Hjelm at Los Alamos National Laboratory in 2002-2003, she returned to research positions in Denmark. Over the last five years she has established a research group at University of Copenhagen that specializes in Small-angle X-ray and Neutron Scattering of biological macromolecules. Lise Arleth became professor in physics in 2011 in the combined fields of "Scattering and Synthetic Biology".

The present central research project of Lise Arleth's group is to develop the so-called nanodisc system into a platform that enables SAXS and SANS based low-resolution structural studies of membrane proteins in solution. This requires a strong joint effort in order to, on one side, control the complex behavior and properties of biological molecules and their self-assembly and on the other hand, develop mathematical modeling software tools to analyze the obtained SAXS and SANS data. Read more?

Lise Arleth has been strongly involved in the European Spallation Source (ESS) project during the last ten years and has been a member of the ESS Scientific advisory committee during the last five years. In the context of her ESS involvement she participates in an instrument design project that has the aim of developing a SANS instrument for the ESS that is fully optimized for investigation of small and weakly scattering biological samples.
 

Alex Holmes, University of Birmingham, United Kingdom

Alex Holmes is a postdoctoral fellow at the University of Birmingham. He studied Natural Sciences at Cambridge University, and received a PhD from the University of Geneva in 2004. He then moved to Osaka University as a JSPS Fellow, followed by a SUPA Advanced Fellowship at the University of St. Andrews before joining the group of Prof.

Ted Forgan in Birmingham in 2009. He started his graduate studies and initial postdoctoral research studying strongly correlated electrons systems and novel mechanisms of superconductivity under extreme pressures. In the last 3 years he has been at the heart of the development of a 17 Tesla cryomagnet for beamline use, which provides the largest field currently available for SANS & SAXS measurements.

It has a sample stage capable of being cooled to 1.6 K for hard condensed matter applications (a further reduction in base temperature by a factor 40 is planned in the near future) and also a room temperature, atmospheric pressure bore which allows the exploitation of magnetic effects in nominally non-magnetic soft matter. 

John Tainer

Dr. Tainer graduated cum laude in Zoology and Anthropology from Trinity College. NC. the worked Scripps control Research Institute, a Member of the Skaggs Institute of Chemical Biology, and Senior Scientist at the Lawrence Berkeley National Lab.

At Berkeley he designed, developed, and runs the combined small angle x-ray scattering (SAXS) SIBYLS (Structurally Integrated BiologY for Life Sciences) to determine accurate structures, conformations and assemblies both in solution and at high resolution (see http://bl1231.als.lbl.gov/).

Dr. Tainer has seven patents for his research and publications control, metalloenzymes, DNA damage responses, and microbial complexes. As in focuses relevant reactive 2) dynamic efforts concern the combination of crystallographic and SAXS technologies for informative aims biology with applications to therapeutics and biotechnology.
 

Michael Gradzielski, Technical University, Berlin, Germany

Michael Gradzielski was born in 1962 in Bayreuth (Germany) and studied chemistry at the Universität Bayreuth (Germany) and the University of Wisconsin – Madison (USA).

He did his dissertation at the Universität Bayreuth on the topic of microemulsions and micromulsion gels in 1992 in the group of Prof. H. Hoffmann. After a post-doctoral stay at the Ecole Normale Superieure,(Paris) with Prof. D. Langevin, he finished his habilitation for Physical Chemistry at the Universität Bayreuth in 2000. Since 2004 he is full professor for Physical Chemistry at the Technische Universität Berlin in the field “Physikalische Chemie/Molekulare Materialwissenschaften”.

In 2010/2011 he stayed 6 months as visiting scientist at the ILL, Grenoble, France. He is a member of various national and international research boards, vice-dean of the faculty II (Mathematics and Natural Science) of the TU Berlin, and received in 2009 the “Raphael-Eduard-Liesegang Preis” of the German Colloid Society for his research contributions in the field of colloids.

His research interests are in the field of soft-matter with a particular emphasis on self-aggregating systems – surfactants and amphiphilic copolymers – but also investigating other colloidal systems such as nanoparticles, biomacromolecules, and mesoporous systems.

The focus of this research is on a detailed structural characterisation of these systems, mostly by employing scattering techniques such as SLS, DLS, SAXS, and SANS but also combining them with other complementary methods. One particular aspect are time-dependent structural investigations of morphological transitions in colloidal systems as for more complex arrangements the formed structures are often metastable and therefore dependent on the pathway of formation.

This detailed structural picture then serves as basis for obtaining thorough insights into the correlation between molecular composition, mesoscopic organisation and the resulting macroscopic properties of the respective systems. The general aim is to go to increasingly complex colloidal systems, to control their functionality and thereby to obtain smart colloidal systems.

Greg Warr, University of Sydney, Australia

Greg Warr has been the Head of the School of Chemistry at the University of Sydney since 2007. He completed his PhD in Physical Chemistry at the University of Melbourne in 1986, became a Fellow of the Royal Australian Chemical Institute in 1998, and was chair of its Division of Colloid and Interface Science from 1998-2000.

During his career he has held visiting appointments at Princeton University, the University of Bordeaux, the Centre Nationale de Recherche Scientifique (CNRS) and the US National Institute of Standards and Technology Center for Neutron Research. He has served on the Editorial Advisory Boards of the Journal of Colloid and Interface Science, Langmuir, and the Australian Journal of Chemistry. Read more?

Our research is aimed at understanding the behaviour of amphiphilic compounds in bulk phases (solutions, lyotropic liquid crystals, complex fluids), in colloidal systems (emulsions, foams, dispersions), and at interfaces. We are pursuing a wide range of projects examining the structure and dynamics of bulk phases and dispersions using techniques including neutron and x-ray scattering (SANS and SAXS), optical microscopy, rheology and calorimetry, and interfacial structure by neutron reflectometry, atomic force microscopy, and surface force measurements.

By combining these techniques we are discovering new structures formed when surface-active molecules adsorb at the solid/liquid interface or when complex fluids abut an interface, and use this to design new nanostructured materials.

Over 130 papers and book chapters have been published on all areas of molecular self-assembly, most recently focussing on amphiphilicity in ionic liquids and novel polymeric amphiphiles.
 

Andrew Allen, NIST, United States

Andrew Allen is a physicist in the Ceramics Division of the Material Measurement Laboratory at the U.S. Department of Commerce’s National Institute of Standards and Technology (NIST), Gaithersburg, Maryland, U.S.A

His main research interests lie in the development and application of advanced neutron and X-ray scattering methods to address measurement barriers in technological materials by means of their microstructure characterization.

Dr. Allen received his Bachelor’s degree from Oxford University, U.K., and both his Master’s degree and Doctorate from the University of Birmingham, U.K. From 1980 to 1991, he worked at the U.K. Atomic Energy Authority’s (later AEA Technology) Harwell Laboratory in England.

During this time, Dr. Allen was primarily concerned with neutron investigations of materials associated with nuclear energy, including SANS characterization of cement, concrete and porous rock relevant to radioactive waste containment. He was also among the first to work in the (then) nascent field of neutron diffraction residual stress measurement.

During a sabbatical from 1988 to 1989 at Northwestern University, Evanston, IL, U.S.A., working on SANS and SAXS studies of high- strength steels, Dr. Allen became acquainted with synchrotron-based SAXS and USAXS, and started several collaborations still thriving today.

Since 1991 Dr. Allen has been based at NIST, and has applied SANS and SAXS methods to many applied materials, including ceramic thermal barrier coatings, nanocrystalline ceramics, modified cements, solid oxide fuel cells, solution-mediated nanoparticle assemblies, dental composites, high-k dielectric films, and advanced CO2 sorbent materials.

Dr. Allen is the author or co-author of some 80 archival journal publications, over 50 conference proceedings and published reports, and has presented 50 invited lectures. Currently, he is Deputy Editor of the Journal of Applied Crystallography.

Peter Fischer, ETH, Switzerland

Greg Peter Fischer studied physics in Regensburg (Germany) and received his PhD from University Essen (Germany) in the group of Heinz Rehage. In 1996/1997 he worked as Postdoc with Gerry Fuller in Chemical Engineering at Stanford University and moved in 1998 to ETH Zurich (Switzerland).

In 2006/2007 he stayed 4 months at the University of Queensland (Brisbane, Australia) with Justin Cooper-White. Research activities focus on soft matter and food material sciences, in particular on interfacial rheology and morphology, viscoelastic surfactant solution, and biopolymers.

He is editor of Applied Rheology and main organizer of the International Symposium of Food Rheology and Structure.
 

Kazuo Sakurai, University of Kitakyushu, Japan

Kazuo Sakurai (KS) is a professor at the department of chemistry and biochemistry in University of Kitakyushu. KS has spent 16 years at the central research center of Kanebo Ltd., (synthetic fibers, functional polymers, and pharmaceutical products) and involved in the fundamental research and business development of conductive polymers for batteries, optical polyester resin, and drug delivering system for insulin.

He spent three years (1990-1993) in US working for Prof. MacKnight in Univ. Mass, and received PhD from Osaka University in 1996. He worked for Pro. Sinkai in JST Project at Kurume from 1999-2001 and has been a professor of the since 2001.

His major research interests are polysaccharides, polysaccharide/polynucleotide complexes, synthesis of lipids for gene delivery, including their biological assays and physical characterization with synchrotron small-angle X-ray scattering. KS has wide-ranging experience within the field of supramolecular chemistry and X-ray scattering. KS published over 100 papers in international peer reviewed journals.

He is also the named inventor on 35 international patents. KS was involved in construction of synchrotron beam BL03XU line at SPring-8. KS is a founder of a bio-venture company. He recently obtained several research funds from CREST/JST and National Institute of Biomedical Innovation (NIBIO), which are well-known as the most competitive funds in Japan.
 

Do Yeung Yoon, Seoul National University, South Korea

Do Y. Yoon received a Ph.D. degree from the polymer science and engineering dept. of Univ. Massachusetts Amherst (1969-1973), did a postdoctoral study with Paul J. Flory in chemistry dept. of Stanford University (1973-1975), and worked in IBM Research Laboratory in San Jose, California as research staff member and manager of polymer physics group (1975-1999).

From 1999 to 2012, he was a professor in chemistry dept. of Seoul National University in South Korea. Currently, he is a consulting professor in chemical engineering dept. of Stanford University.

His research areas include molecular conformations, dynamics and morphology of polymers, surface and thin film characteristics, and structure-property relationships of polymers for nanoelectronics, optoelectronics, and fuel cells. 
 

Dr Nozomi Ando, MIT, United States

Following her physics education at MIT, Dr. Nozomi Ando performed her PhD research on the topic of protein folding thermodynamics in the group of Prof. Sol Gruner (Cornell Physics).

Currently, she is conducting her postdoctoral research on metalloenzymes with importance to health and environment in the group of Prof. Catherine Drennan (MIT Chemistry). Dr. Ando has expertise in the molecular biophysics of proteins, both in the context of folding and function.

Small-angle X-ray scattering (SAXS) is a primary tool in her research. Her recent accomplishments include the deconvolution of rapidly interconverting states in ribonucleotide reductase (a central enzyme in DNA metabolism) using SAXS, in understanding their roles in allosteric regulation.

As a recent recipient of the Pathway to Independence Award from the National Institutes of Health, she looks forward to new challenges in the investigation of dynamic enzymes and interacting protein systems.

Dr Aaron Eberle, ExxonMobil Research and Engineering, USA

Dr. Aaron Eberle is a Senior Research Scientist in ExxonMobil Research and Engineering at Clinton, New Jersey, USA. He completed his PhD in Chemical Engineering at Virginia Tech (USA) in 2008 where he studied in the areas of polymer processing and rheology.

Following his doctorate he held a postdoctoral position at the University of Delaware (USA) working under the guidance of Prof. Norman Wagner, and afterward he was awarded a National Research Council fellowship at the NIST Center for Neutron Research (USA) where he worked with Dr. Paul Butler.

During his postdoctoral appointments Dr. Eberle studied the fundamentals of gelation, structure at interfaces, and flow-induced structural reorganization in model particulate systems utilizing small-angle neutron scattering (SANS) and neutron reflectivity (NR).

This work was completed in connection with the development of state-of-the-art sample environments that combine flow with scattering, and data acquisition modules for time resolved measurements designed in a collaborative effort with Dr. Lionel Porcar at the Institute Laue Langevin (ILL, Grenoble, France). Currently, Dr. Eberle leads the efforts within ExxonMobil to apply scattering to problems of industrial importance that encompasses both hard and soft matter.

Dr Daniel Franke, European molecular biology laboratory, Germany

Daniel Franke received a degree in Mathematics at the University of Applied Sciences in Darmstadt, Germany, in 2002 and in 2006 his PhD in human biology at the Medical University in Luebeck, Germany. Since then, he is working as a post-doc and staff member in the BioSAXS group of the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany.

His research focuses on methods development for Small Angle X-Ray Scattering (SAXS), in particular on the experiment setup and data analysis for biological macromolecules in solution.

He is an author of several publicly available programs from the ATSAS computer package, including cross platform versions of data analysis and visualization tools, and the rapid ab initio shape determination program DAMMIF (2009).

His work on BioSAXS beamline automation not only allows for unattended and autonomous (2012), but also for remote operation of the beamlines. The first remote experiments in biological SAXS were conducted in 2009.

In the frame of the WeNMR initiative (http://wenmr.org) he establishes contacts with the NMR methods developers and works to make the computational resources of the grid available to the SAS community

Cy Jeffries, ANSTO, Australia

Cy Jeffries is currently a postdoctoral fellow at the Australian Nuclear Science and Technology Organisation and a former research associate of the University of Sydney specialising in the application of small-angle scattering techniques to probe the organisation of biomacromolecules and their complexes in solution.

His research background incorporates an array of diverse techniques in the field of structural molecular biology - which includes but is not limited to (i) the design and cloning of genes and strategies for the over expression and isolation of recombinant proteins (ii) the optimisation of sample conditions for both small-angle X-ray (SAXS) and neutron scattering (SANS) (iii) the subsequent computational modelling and analysis of scattering data.

His interest in SAXS and SANS is rooted in their deep methodological elegance as well as their efficacy - indeed, their provisioning of complementary structural information that arguably prompts the genesis of novel insights which might otherwise evade the scrutiny of more traditional structural biological techniques.

Dr Kathryn Krycka, National institute of standards and technology, United States

Kathryn Krycka received a Bachelor of Science from the University of Massachusetts and a Doctor of Philosophy in Physics from the State University of New York at Stony Brook in 2007.

During her graduate career she studied the behavior of ultra-thin magnetic thin films using a combination of multi-energy resonant x-ray scattering and x-ray magnetic circular dichroism with advisor Dr. Chi-Chang Kao at the Brookhaven National Laboratory. She then joined the NIST Center for Neutron Research (NCNR) as a National Research Council post-doctoral researcher with advisor Dr. Julie Borchers.

There she utilized the newly available, high-polarization 3He spin filters of capable of analyzing a divergently scattered beam to study magnetic patterned media and self-assembled nanoparticles. Since 2009 she has continued on at the NCNR as research staff member with the specialization of neutron spin analysis. Read more?

In particular, Kathryn has developed polarization analysis capabilities for small-angle neutron scattering that allow the underlying magnetic morphology to be determined with vectorial sensitivity. This has provided new insight into how the “missing” spins are collectively arranged within close-packed nanoparticle systems.

Other developments have included the time-dependent polarization-leakage correction software, Pol-Corr, and mathematical algorithms designed specifically to analyze non-isotropic systems. The latter is currently being implemented into the SANSView/SASView data fitting and analysis suite for general usage by the scattering community.
 

Dr Tomotaka Oroguchi, Keio University, Japan

Dr. Tomotaka Oroguchi received a B.S. degree in Engineering in 2002, and a Ph.D. degree in Science from The University of Tokyo in 2007. In his Ph.D. research, he characterized the structural changes along protein folding in atomic details using kinetic experiments and molecular dynamics (MD) simulations in the group of Prof. Kunihiro Kuwajima.

He then joined the group of Prof. Mitsunori Ikeguchi at Yokohama City University as a postdoctoral fellow. Currently, he is an Assistant Professor in the group of Prof. Masahiro Nakasako in the Department of Physics at Keio University. Read more?

One of his major research interests is the relationship between protein dynamics and functions. To detect protein structures in solution at an atomic resolution, he has developed the novel structural analysis method called MD-SAXS, which combines small-angle X-ray solution scattering (SAXS) experiments and all-atom MD simulations.

One of the innovations of this method is that it enables correct evaluation of X-ray scattering from explicit water molecules hydrating proteins. Therefore MD-SAXS offers a link between the low-resolution structural information from SAXS and three-dimensional high-resolution structures, and has revealed the importance of intrinsic dynamics of a DNA-binding protein, EcoO109I, in its function.

His recent research activities include structure-function analyses of intrinsically disordered proteins using MD-SAXS, and development of novel structural analysis method by coherent X-ray diffraction microscopy.

Dr Adam Perriman, University of Bristol, United Kingdom

Adam Perriman‘s research career began in 2002 at the Australian National University where he won an AINSE Postgraduate Research Award to study under the tutorage of Professor John White before taking up a Postdoctoral research position with Prof.

Steve Mann in 2007 at the Centre of Organized Matter Chemistry, University of Bristol. In 2010 he was awarded an Engineering and Physical Research Council (EPSRC) Postdoctoral Fellowship supported by the Cross-Disciplinary Interfaces program, and his recent research efforts have been focused on the unprecedented development of novel solvent-free protein liquids.

His work has been featured nationally in Nature, Nature Materials, RSC’s Chemistry World and The Chemical Engineer, and internationally in the ACS’s Chemical and Engineering News (C&EN), Medical News, The Engineer, and In Pharma. In 2010 he was interviewed on BBC 4’s Material World, which was broadcast live nationally. Read more?

SAS has featured as the primary technique in Perriman’s research, and he has successfully applied SANS to help elucidate the structure of the synthetic virus-like particles (SVLPs) {collaboration involving Prof. J. Robinson (Uni. Zurich), Dr. A. Jackson (NIST) and Dr. I. Grillo (ILL) (ChemBioChem, 2011)}, and developed a synthetic strategy to produce novel hybrid constructs incorporating ultra-thin layers of amorphous calcium phosphate (Small, 2010).

Other ongoing SAS-based research includes the use of Synchrotron Radiation SAXS to study the electric field-driven re-orientation of gold nanorods dispersed in thermotropic liquid crystals; and the assembly of artificial light harvesting complexes using pressure-induced dissociation and re-association of bacterial ferritins.

Perriman’s recent research efforts have also been focused on understanding the structures and interactions in solvent-free liquid proteins. Specifically, he has used contrast variation SANS at the Institut Laue-Langevin and ISIS to probe the structures of liquid myoglobin and green fluorescent protein (GFP) and their aqueous precursors at nanometer resolution.

Dr Yuya Shinohara, The University of Tokyo, Japan

Yuya Shinohara received his PhD from The University of Tokyo (2011) and has been an assistant professor in the group of Professor Yoshiyuki Amemiya since 2007.

His research activities focus on SAXS and its application to soft matters. He has worked on the development of SAXS techniques, including time-resolved two-dimensional USAXS, microbeam SAXS, anomalous SAXS at low energy, X-ray near-field scattering, and X-ray Photon Correlation Spectroscopy (XPCS).

He has developed XPCS at SPring-8 and applied it to industrial materials such as rubber filled with nanoparticles. His major research interests are relationship between macroscopic properties of soft matters and their spatially/temporally hierarchical structures

Dr llia Voets, Eindhoven University of Technology, Netherlands

Dr. Ilja Voets graduated cum laude in Molecular Sciences in 2004 from Wageningen University (the Netherlands). She obtained her PhD degree in the Physical Chemistry and Colloid Science group of Prof. Martien Cohen Stuart cum laude from the same university in 2008.

She spent two years as a Marie Curie postdoctoral fellow at the Aldolphe Merkle Institute at the University of Fribourg (Switzerland) in the group of Prof. Peter Schurtenberger.

Currently, she is an Assistant Professor in the Department of Chemical Engineering and Chemistry and the Institute for Complex Molecular Systems at Eindhoven University of Technology, TU/e (the Netherlands).

Her research focuses on self-assembly processes in biological and soft matter to gain fundamental insights and support the development of rational design strategies for novel functional soft materials.

Research activities include electrostatically driven self-assembly of copolymers and proteins, self-assembly of chiral supramolecular polymers and colloids, conformational transitions of graft copolymers and polymer-peptide conjugates, and structure-property relationships of anti-freeze proteins.