Mr Nicholas R Howell

Position: Cell Biology Professional Officer
Phone: +61 (0)2 9717 3071
Email: nicholas.howell@ansto.gov.au
 

Role at ANSTO

Nicholas works in the Bioanalytics group under Prof. Richard Banati providing expertise and support for the in vitro evaluation of novel compounds, peptides, proteins and particles. He also provides expertise and support for the analytical biology requirements of ANSTO LifeSciences and its collaborators in radiological and nuclear methodologies for applications.

Background

Graduating from Macquarie University with BSc in Biotechnology, Nicholas has  been working at ANSTO as a biologist for 5 years.

Research interests and areas of expertise

Nicholas has expertise and interest in the application of radiological and nuclear techniques to the analysis of biological systems and structures. Other areas of expertise include in vitro pharmacology, RT-qPCR, immunohistochemistry, cell culture.

Key Publications

Szabo, A. M., Howell, N. R., Pellegrini, P., Greguric, I., Katsifis, A.  Development and validation of competition binding assays for affinity to the extracellular matrix receptors, αvβ3 and αIIbβ3 integrin. Analytical Biochemistry, 423(1) 70-77. (2012)

Peyronneau, M., Mattner, F., Howell, N., Jiang, C., Pellegrini, P., Greguric, I., Loch, C., Katsifis, A. Metabolism of CLINDE, a peripheral benzodiazepine receptor SPECT ligand. European Journal of Nuclear Medicine and Molecular Imaging, 37(2), S242. (2010)

Mattner, F., Pham, T., Berghofer, P., Howell, N., Bourdier, T., Rahardjo, G., Kench, P. L., Zahra, D., Gregoire, M-C., Katsifis, A. Pharmacological evaluation of the Peripheral Benzodiazepine Receptor radioligand [123I]-CLINDE in a breast tumour model. 57th Annual Meeting of the Society of Nuclear Medicine, 5th – 9th June, Salt Lake City, UT, USA. (2010)

Mattner, F., Berghofer, P., Shepherd, R., Howell, N., Pham, T., Bourdier, T., Ballantyne, P., Katsifis, A. Ex vivo pharmacological evaluation of the Peripheral Benzodiazepine Receptor radioligand [123I]CLINDE in animal tumour model. 38th Annual Meeting of the Australia and New Zealand Society of Nuclear Medicine, 1st – 6th May, Gold Coast, Australia. (2008)