Ms Anwen Krause-Heuer

Position: F-18 Radiochemistry Postdoctoral Fellow
Phone: +61 (0)2 9717 7703
Email: anwen.krause-heuer@ansto.gov.au
 

Role at ANSTO

Anwen commenced her current role as F-18 Radiochemistry Postdoctoral Fellow in February 2012. Her research focus is the synthesis and radiolabelling of new fluorinated tracers for imaging Alzheimer’s disease, as part of a collaborative project with Massachusetts General Hospital (USA) and the Mental Health Research Institute (Melbourne, Australia).

Background

Anwen is currently in the final stages of submitting her PhD in medicinal inorganic chemistry at the University of Western Sydney under the supervision of Professor Janice Aldrich-Wright. Anwen joined LifeSciences in 2011 as part of the Graduate Development Program.

Qualifications & Achievements

PhD (University of Western Sydney)- current
Grad.Cert. Res. Comm.- University of Technology, Sydney, 2010
BSc (Hon., Class I)- University of Western Sydney, 2007
BSc (Adv. Sci.)- University of Western Sydney, 2006

Anwen was awarded the Royal Society of NSW Scholarship in 2012 and the University Medal from the University of Western Sydney in 2008.

Anwen is a member of the Royal Australian Chemical Society (MRACI) and Women in Nuclear (WiN).

Key Publications

Fraser. B. H., Hamilton, S. Krause-Heuer, A. M., Wright, P., Greguric, I. Tucker, S., Draffan, A., Fokin , V., Sharpless, K. B., Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B. MedChemComm, advance article. DOI: 10.1039/C2MD20300F (2012)

Krause-Heuer, A. M., Howell, N. R., Matesic, L., Dhand, G., Young, E. L., Burgess, L., Jiang, C. D., Lengkeek, N. A., Fookes, C. J. R., Pham, T. Q., Sobrio, F., Greguric, I., Fraser, B. H. A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis. MedChemComm, advance article. DOI:10.1039/C2MD20249B (2012)

Krause-Heuer, A. M., Price, W. S., Aldrich-Wright, J. R., Spectroscopic investigations on the interactions of potent platinum(II) anticancer agents with bovine serum albumin, Journal of Chemical Biology, 5, 105-113. DOI:10.1007/s12154-012-0074-1 (2012)

Krause-Heuer, A. M., Leverett, P., Bolhuis, A., Aldrich-Wright, J. R. Copper(II) and palladium(II) complexes with cytotoxic and antibacterial activity. Australian Journal of Chemistry, 65, 860-873. DOI:10.1071/CH12058 (2012)

Garbutcheon-Singh, K. B., Grant, M. P., Harper, B. W., Krause-Heuer, A. M., Manohar, M., Orkey, N. U., Aldrich-Wright, J. R. Transition metal based anticancer drugs. Current Topics in Medicinal Chemistry, 11, 521-542. DOI:10.2174/156802611794785226 (2011)

Harper, B. W., Krause-Heuer, A. M., Grant, M. P., Manohar, M., Garbutcheon-Singh K. B., Aldrich-Wright, J. R. Advances in platinum chemotherapeutics. Chemistry - A European Journal, 16, 7064-7077. DOI:10.1002/chem.201000148 (2010)

Krause-Heuer, A. M., Grünert, R., Kühne, S., Maruszak, M., Wheate, N. J., Le Pevelen, D., Boag, L., Fisher, D. M., Kasparkova, J., Malina, J., Bednarski, P.J., Brabec, V., Aldrich-Wright, J. R. Studies into the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells. Journal of Medicinal Chemistry. 52, 5474-5484. DOI:10.1021/jm9007104 (2009)

Krause-Heuer, A. M., Wheate, N. J., Price, W. S., Aldrich-Wright, J. R. Diffusion-based studies on the self-stacking and nanorod formation of platinum(II) intercalators. Chemical Communications, 9, 1210-1212. DOI:10.1039/B820584A (2009)

Krause-Heuer, A. M., Wheate, N. J., Tilby, M. J., Pearson, D. G., Ottley, C. J. , Aldrich-Wright, J. R. Substituted β-cyclodextrin and calix[4]arene as encapsulatory vehicles for platinum(II)-based DNA intercalators. Inorganic Chemistry, 47, 6880-6888. DOI:10.1021/ic800467c (2008)

Finnie, K. S., Waller, D. J., Perret, F. L., Krause-Heuer, A. M., Lin, H. Q., Hanna J. V., Barbé, C. J. Biodegradability of sol-gel silica microparticles for drug delivery. Journal of Sol-Gel Science and Technology, 49, 12-18. DOI:10.1007/s10971-008-1847-4 (2008)

Krause-Heuer, A. M., Grant, M. P., Orkey, N., Aldrich-Wright, J. R. Drug delivery devices and targeting agents for platinum(II) anticancer complexes. Australian Journal of Chemistry, 61, 675-681. DOI:10.1071/CH08157 (2008)

Wheate, N. J., Taleb, R ., Krause-Heuer, A. M., Cook, R. L., Wang, S., Higgins, V. J., Aldrich-Wright, J. R. Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles. Dalton Transactions, 43, 5055-5064. DOI:10.1039/B704973K (2007)
 

Krause-Heuer, A. M., Manohar, M., Garbutcheon-Singh, K. B., Fisher, D. M., Aldrich-Wright, J. R. Chapter 3 The Synthesis of Platinum(II) Intercalators, Metallointercalators, Synthesis and Techniques to Probe Their Interactions with Biomolecules, J. Aldrich-Wright (Ed.), (2010), ISBN 978-3-211-09427-3.

Zheng, G. Krause-Heuer, A. M., Price, W. S. Chapter 7 Pulsed Gradient Spin-Echo NMR, Metallointercalators, Synthesis and Techniques to Probe Their Interactions with Biomolecules, J. Aldrich-Wright (Ed.), (2010), ISBN 978-3-211-09427-3.