Dr Rachael Shepherd

Position: Cell Biologist
Phone: +61 (0)2 9717 9413
Email: rachael.shepherd@ansto.gov.au
 
 

Role at ANSTO

Rachael works with in vitro analysis of novel compounds and radiotracers, developing in vitro techniques, and identifying and analysing new radiotracer targets.

Background

Before joining LifeSciences in 2005, Rachael completed her PhD at the University of Sydney in which she investigated the role of apoptosis in the pathophysiology of mitochondrial disorders. Rachael's primary role within LifeSciences is to investigate novel radiotracers or potential targets using in vitro techniques.

Research interests and areas of expertise

Rachael’s areas of expertise include cell culture, immunofluorescence assays, histology, radioligand binding assays, radiotracer cell uptake assays, and in vivo radiotracer analysis.

Qualifications & Achievements

PhD at the University of Sydney (2007)

Key Publications

Denoyer, D., Kirby, L., Waldeck, K., Roselt, P., Neels, O. C., Bourdier, T., Shepherd, R., Katsifis, A., Hicks, R. J. Preclinical characterization of 18F-D-FPHCys, a new amino acid-based PET tracer. European Journal of Nuclear Medicine and Molecular Imaging. (in press, 2012)

Bourdier, T., Shepherd, R., Berghofer, P., Jackson, T., Fookes, C. J., Denoyer, D., Dorow, D., Greguric, I., Gregoire, M-C., Hicks, R. J., Katsifis, A. Radiosynthesis and biological evaluation of L and D S-(3-[18F]Fluoropropyl)-homocysteine for tumor imaging using positron emission tomography. Journal of Medicinal Chemistry, 54(6), 1860-1870. (2011)

Fookes, C. J. R., Pham, T. Q., Mattner, F., Greguric, I., Loc’h, C., Liu, X., Berghofer, P., Shepherd, R., Gregoire, M-C., Katsifis, A. Synthesis and biological rvaluation of substituted [18F]Imidazo[1,2-a]pyridines and [18F]Pyrazolo[1,5-a]pyrimidines for the study of the Peripheral Benzodiazepine Receptor using Positron Emission Tomography. Journal of Medicinal Chemistry, 51(13), 3700-3712. (2008)