ANSTO's research capabilities, led by the OPAL nuclear research reactor and associated instruments provide access to users investigating areas as diverse as materials, life sciences, climate change and mining/engineering.
Radio-halogen and -carbon Probes
Our radio-halogen and –carbon probe research involves the use of 11C, 18F and radioiodine (123I, 124I, 125I and 131I) isotopes for radiolabelling compounds and biological reagents.
The group engages with applied research, radiosynthesis of radiopharmaceuticals and fundamental research programs:
- Development of new radiosynthons,
- Reagents, and
- Radiolabelling methodologies using macro and microfluidic modules.
Predominantly diagnostic radiopharmaceuticals are developed within this theme.
Dr Ivan Greguric, Head of Radiochemistry, leads our radiochemistry research, supported by Dr Tien Pham and Dr Giancarlo Pascali, Radiochemistry task leaders, and Dr Ben Fraser, Organic Chemistry task leader.
Radio-halogen and –carbon probe capabilities
- Development and optimisation of cell, peptide, protein, or nanoparticle radiolabelling
Contact scientists: Tien Pham, Giancarlo Pascali, Paul Pellegrini, and Ivan Greguric
- Development/discovery of ‘cold’ fluorination reactions and translation into ‘hot’ 18F radiolabelling reactions
Contact scientists: Giancarlo Pascali, Tien Pham, Ben Fraser
- Synthesis of 18F, 11C, radio-iodine radiotracer cold standards and labelling precursors
Contact scientists: Ben Fraser, Tien Pham, Giancarlo Pascali
- Radiometabolite analysis - radioHPLC, radioTLC methods, and solid phase extraction methods
Contact scientists: Tien Pham, Maxine Roberts, Naomi Wyatt
- Radiopharmaceuticals - synthesis of small compound libraries for in vitro and in vivo evaluation as new radiopharmaceuticals
Contact scientists: Ben Fraser, Nigel Lengkeek