Dr Arnaud Charil

Imaging Group Leader
Phone - +61 2 9717 9501
   
Arnaud Chari staff profile image

Profile

Role at ANSTO

Arnaud’s role at ANSTO LifeSciences is to manage the Imaging group within ANSTO LifeSciences, lead strategically aligned research and assist in the development of ANSTO’s future imaging capability including initiation/participation in internal and external international & national collaborations. 
 
Background
 
After obtaining his MSc in Radiation and Medical Imaging from the Paul Sabatier University in Toulouse, France, Arnaud moved to Canada in 2000 and completed a PhD in Neurological Sciences at McGill University - Montreal Neurological Institute, looking at the morphological and functional correlates of disability in multiple sclerosis.

Arnaud spent a year at the Scientific Institute and University Ospedale San Raffaele in Milan, Italy, and went to Harvard University/Brigham and Women's Hospital as a postdoctoral fellow to investigate novel aspects of brain imaging in MS. Arnaud also spent 3 years at the Douglas Mental Health University Institute in Montreal as a postdoctoral fellow to manage a brain imaging study on the noxious effects of prenatal maternal stress on human brain development in over 130 11 year-old children.

Arnaud then worked from 2010 to 2014 as a Neuroimaging Research Scientist and Study Director at Biospective Inc., a Montreal-based leading CRO specializing in animal & human imaging and histopathology services (CNS diseases including Alzheimer’s disease). In 2014, he joined ANSTO LifeSciences.
 
Research interests and areas of expertise
 
Preclinical Imaging, Clinical Neuroimaging (MRI & PET), Multiple Sclerosis, Prenatal Stress and Brain Development, Alzheimer’s Disease.
 
Qualifications & achievements 
 
  • Honorary Research Fellow, Faculty of Health Sciences, the University of Sydney (2014)
  • PhD in Neurological Sciences, McGill University, Department of Neurology and Neurosurgery, Montreal Neurological Institute, Montreal, Canada (2007)
  • MSc in Radiation and Medical Imaging, Paul Sabatier University, Toulouse, France (1999)
  • BSc in Cell Biology and Animal Physiology, Rennes I University, Rennes, France (1998)
 
 

Selected publications

Garcia, M. P., Charil, A., Callaghan, P., Wimberley, C., Busso, F., Gregoire, M-C., Bardies, M., Reilhac A. OSSI-PET: Open-access database of Simulated 11C Raclopride Scans for the Inveon preclinical PET scanner: Application to the optimization of reconstruction methods for dynamic studies. IEEE Transactions on Medical Imaging. 2016. In Press


Reilhac, A., Boisson, F., Wimberley, C., Parmar, A., Zahra, D., Hamze, H., Davis, E., Arthur, A., Bouillot, C., Charil, A., Grégoire, M-C. Simultaneous scanning of two mice in a small-animal PET scanner: a simulation-based assessment of the signal degradation. Phys Med Biol. 2016 Jan 21;61(3):1371-1388.


Carbonell, F., Zijdenbos, A. P., Charil, A., Grand'Maison, M., Bedell, B. J. Alzheimer’s Disease Neuroimaging Initiative. Optimal Target Region for Subject Classification on the Basis of Amyloid PET Images. J Nucl Med. 2015;56:1351-8.


Reilhac, A., Charil, A., Wimberley, C., Angelis, G., Hamze, H., Callaghan, P., Garcia, M. P., Boisson, F., Ryder, W., Meikle, S. R., Gregoire, M-C. 4D PET iterative deconvolution with spatiotemporal regularization for quantitative dynamic PET imaging. Neuroimage. 2015;118:484-93.


Carbonell, F., Charil, A., Zijdenbos, A. P., Evans, A. C., Bedell, B. J. for the Alzheimer's Disease Neuroimaging Initiative. Hierarchical multivariate covariance analysis of metabolic connectivity. J Cereb Blood Flow Metab. 2014;34:1936-43.


Carbonell, F., Charil, A., Zijdenbos, A. P., Evans, A. C., Bedell, B. J. β-Amyloid is associated with aberrant metabolic connectivity in subjects with mild cognitive impairment. J Cereb Blood Flow Metab. 2014;34:1169-79.


Charil, A., Inglese, M. Predicting short-term conversion from CIS to MS: Relevance of lesion distribution. Neurology. 2013;80:230-1.


Holland, C., Charil, A., Csapo, I., Liptak, Z., Ichise, M., Khoury, S., Bakshi, R., Guttmann, C., Weiner, H. Normal cerebral perfusion patterns and white matter lesion distributions in 1,249 multiple sclerosis patients. J Neuroimaging 2012; 22:129-36.


Charil, A., Laplante, D. P., Vaillancourt, C., King, S. Prenatal stress and brain development. Brain Res Rev 2010; 65:56-79.


Charil, A., Corbo, M., Filippi, M., Kesavadas, C., Agosta, F., Munerati, E., Gambini, A., Comi, G., Scotti, G., Falini, A. Structural and metabolic changes in the brain of patients with upper motor neuron disorders: a multiparametric MRI study. Amyotroph Lateral Scler 2009; 10:269-79.


He, Y., Dagher, A., Chen, Z., Charil, A., Zijdenbos, A. P., Worsley, K. J., Evans, A. C. Impaired small-world efficiency in structural cortical networks in multiple sclerosis associated with white matter lesion load. Brain 2009; 132:3366-79.


Mesaros, S., Rocca, M. A., Sormani, M. P., Charil, A., Comi, G., Filippi, M. Clinical and conventional MRI predictors of disability and brain atrophy accumulation in RRMS : A large scale, short-term follow-up study. J Neurol 2008; 255:1378-83.


Liptak, Z., Berger, A. M., Sampat, M. P., Charil, A., Felsovalyi, O., Healy, B. C., Hildenbrand, P., Khoury, S. J., Weiner, H. L., Bakshi, R., Guttmann, C. R. Medulla Oblongata Volume: A Biomarker of Spinal Cord Damage and Disability in Multiple Sclerosis. AJNR Am J Neuroradiol 2008; 29:1465-70.


Charil, A., Filippi, M. Inflammatory Demyelination and Neurodegeneration in Early MS. J Neurol Sci 2007; 259: 7-15.


Charil, A., Dagher, A., Lerch, J. P., Zijdenbos, A. P., Worsley, K. J., Evans, A. C. Focal Cortical Atrophy in Multiple Sclerosis: Relation to Lesion Load and Disability. NeuroImage 2007; 34: 509-517.


Charil, A., Yousry, T., Rovaris, M., Barkhof, F., De Stefano, N., Fazekas, F., Miller, D. H., Montalban, X., Simon, J. H., Polman, C., Filippi, M. MRI and the Diagnosis of MS: Expanding the Concept of "No Better Explanation". Lancet Neurol 2006; 5:841-852.


Charil, A., Caputo, D., Cavarretta, R., Sormani, M. P., Ferrante, P., Filippi, M. Cervical Cord MTR and Clinical Changes Over 18 Months in Patients with relapsing-Remitting MS: a Preliminary Study. Mult Scler 2006; 12: 662-665.


Oreja-Guevara, C., Charil, A., Caputo, D., Cavarretta, R., Sormani, M. P., Filippi, M. MT MRI Reflects Clinical Changes Over 18 Months in Relapsing-Remitting MS Patients. Arch Neurol 2006; 63: 736-740.


Benedetti, B., Charil, A., Rovaris, M., Judica, E., Valsasina, P., Sormani, M. P., Filippi, M. Influence of aging on brain gray and white matter changes assessed by conventional, MT, and DT MRI. Neurology 2006; 66: 535-539.


Charil, A., Zijdenbos, A. P., Taylor, J., Boelman, C., Worsley, K. J., Evans, A. C., Dagher, A. Statistical mapping analysis of lesion location and neurological disability in MS: application to 452 patient data sets. NeuroImage 2003;19:532-544.