Dr Tamim Darwish

Team leader- Chemical Deuteration
Phone - +61 2 9717 9080
   
Tamim Darwish image 180x180px

Profile

Role at ANSTO


Tamim is the chemical deuteration team leader at the National Deuteration Facility (NDF) at ANSTO. His responsibilities lie primarily in developing the capability of the chemical deutetration facility for the synthesis and characterization of organic molecules labelled with deuterium, and collaborating with researchers who are interested in labelling  compounds for their experiments.
 

He is interested in developing new methods for the synthesis of deuterated organic and polymeric molecules, as well as, deuterated unsaturated fatty acids and surface functional deuterated lipids for neutron scattering, NMR, IR and other techniques. Tamim has background in organic / organometallic synthesis and NMR spectroscopy.
 

Expertise
 

Deuterium Labeling, NMR Spectroscopy, Photochromism, Organic/Organometallic Synthesis, Photochemistry, Self-Assembled Monolayer.


Qualifications & Achievements

 

  • Postdoctoral Research Fellow, ANSTO-Institute of Materials Engineering (2007-2008)
  • Postdoctoral Research Fellow, University of Sydney (2006-2007)
  • Ph.D. in Chemistry, University of New South Wales (2006)
     

Committees, memberships & affiliations

  • JSPS Fellowship, Sep 2010, Hokkaido University, CRC, Japan.
  • Member of the Royal Australian Chemical Institute, MRACI since 2001.
  • Member of the Australian Research Council Nanotechnology Network.
  • School of Chemistry UNSW Teaching Fellowship (2003-2006).
  • EUROMAR grant, EUROMAR conference, Veldhoven, Netherlands (2005).
  • Worked as an LC-MS organic chemist in the food and environmental analytical industry (1999-2003).
     

 

 

Selected publications

Salentinig, S; Yepuri, N; Hawley, A; Boyd, B; Gilbert, E; Darwish, T, “Selective deuteration for molecular insights into the digestion of medium chain triglyceridesChemistry and physics of lipids 2015, 190, 43-50. 
 
Kent, B; Hauß, T; Demé, B; Cristiglio, V; Darwish, T; Hunt, T; Bryant, G; Garvey, C, “Direct comparison of disaccharide interaction with lipid membranes at reduced hydrationsLangmuir, 2015, 31 (33), 9134-9141. 
 
Danos, A; MacQueen, R; Cheng, Y; Dvorák, M; Darwish, T;  McCamey, D; Schmidt T, “Deuteration of perylene enhances photochemical upconversion efficiencyThe journal of physical chemistry letters, 2015, 6 (15), 3061-3066. 
 
Russell, R; Garvey, C; Darwish, T; Foster, LJ; Holden P, “Biopolymer Deuteration for Neutron Scattering and Other Isotope-Sensitive Techniques”, (Book Chapter) Methods in Enzymology, Academic Press, 2015.
 
 
Ge, A;  Peng, Q; Qiao, L; Yepuri, N;  Darwish, T;  Matsusaki, M; Akashi, M;  Ye, S, “Molecular orientation of organic thin films on dielectric solid substrates: a phase-sensitive vibrational SFG study”, Physical Chemistry Chemical Physics, 2015, 17 (27), 18072-18078. 
 
 
Darwish, N;  Aragones, A; Darwish, T; Ciampi, S; Díez-Pérez, I, “Multi-Responsive Photo- and Chemo-Electrical Single-Molecule SwitchesNano Letters, 2014, 14(12), 7064-7070.
 
Queen, W; Hudson, M; Bloch, E; Mason, J; Gonzalez, M; Lee, J; Gygi, D; Howe, J; Lee, K; Darwish, T;  James, M; Peterson, V; Teat, S; Smit, B; Neaton, J; Long, J; Brown, C, “Comprehensive study of carbon dioxide adsorption in the metal–organic frameworks M2(dobdc) (M = Mg, Mn, Fe, Co, Ni, Cu, Zn)Chemical Science, 2014, 5, 4569–4581
 
Vanston, C; Kearley, G;  Edwards, A; Darwish, T; Desouza, N;  Ramirez-Cuesta, A; Gardiner, M, “The free-energy barrier to hydride transfer across a dipalladium complexFaraday Discussion, 2014, DOI: 10.1039/c4fd00182f
 
Phan, S; Salentinig, S; Gilbert, E; Darwish, T; Hawley, A; Nixon-Luke, R; Bryant, G; Boyd, B, “Disposition and crystallization of saturated fatty acid in mixed micelles of relevance to lipid digestionJournal of Colloid & Interface Science, 2014, doi:10.1016/j.jcis.2014.11.026
 
Krause-Heuer, A;  Yepuri, R; Darwish, T; Holden, P, “Mild Conditions for Deuteration of Primary and Secondary Arylamines for the Synthesis of Deuterated Optoelectronic Organic MoleculesMolecules, 2014, 19(11), 18604-18617.
 
Kent, B; Hunt, T; Darwish, TA; Hauß, T; Garvey, CJ and Bryant, G, “Localization of trehalose in partially hydrated DOPC bilayers: insights into cryoprotective mechanismsJ. R. Soc. Interface 2014, 11, 95. 
 
Russell, RA; Darwish, TA; Puskar, L; Martin, DE; Holden, PJ and Foster, LJR, “Deuterated Polymers for Probing Phase Separation Using Infrared Microspectroscopy", Biomacromolecules 2014, 15(2), 644-649.
 
Salentinig, S; Phan, S; Darwish, TA; Kirby, N; Boyd, BJ and Gilbert, EP, “pH-Responsive Micelles Based on Caprylic Acid", Langmuir” 2014, 30, 7296-7303.
 
Wu, Y; Peterson, VK; Luks, E; Darwish, TA and Kepert, CJ, “Interpenetration as a Mechanism for Negative Thermal Expansion in the Metal-Organic Framework Cu3(btb)2 (MOF-14)Angew. Chem.-Int. Edit. 2014, 53(20), 5175-5178. 
 
Yepuri, NR; Holt, SA; Moraes, G; Holden, PJ; Hossain, KR; Valenzuela, SM; James, M and Darwish, TA, “Stereoselective synthesis of perdeuterated phytanic acid, its phospholipid derivatives and their formation into lipid model membranes for neutron reflectivity studiesChem. Phys. Lipids, 2014, 183, 22-33.
 

Tangso, K. J.; Fong, W. K.; Darwish T.; Kirby, N.; Boyd, B. J.; Hanley, T. L. “Novel Spiropyran Amphiphiles and Their Application as Light-Responsive Liquid Crystalline Components” J. Phys. Chem. B,2013, 117 (35), 10203–10210.
 

Darwish, T. A.; Luks, E.; Moraes, G.; Yepuri, N. R.; Holden, P. J.; James, M. “Synthesis of deuterated [D32]oleic acid and its phospholipid derivative [D64]dioleoyl-sn-glycero-3-phosphocholine” Journal of Labelled Compounds and Radiopharmaceuticals, 2013, 56, 520-529.
 

Ge, A.; Wu, H.; Darwish, T. A.; James, M.; Osawa, M.; Ye S. “Structure and Lateral Interaction in Mixed Monolayers of Dioctadecyldimethylammonium Chloride (DOAC) and Stearyl Alcohol” Langmuir, 2013, 29 (18), 5407-5417.
 

Le Brun, A. P.; Darwish, T. A.; James, M. “Studies of Biomimetic Cellular Membranes Using Neutron Reflection” J. Chem. Biol. Interfaces, 2013, 1, 3-24.

Yepuri, N. R.; Jamieson, S. A.; Darwish, T. A.; Rawal, A.; Hook, J. M.; Thordarson, P.; Holden, P. J.; James, M. “Synthesis of per-deuterated alkyl amines for the preparation of deuterated organic pyromellitamide gelators” Tetrahedron Letters, 2013, 54, 2538-2541.
 

Darwish, T. A.; Tong, Y.; James M.; Hanley, T. L.;  Peng, Q.;  Ye S.  "Characterizing the Photoinduced Switching Process of a Nitrospiropyran Self-Assembled Monolayer Using In Situ Sum Frequency Generation Spectroscopy" Langmuir, 2012, 28 (39), pp 13852–13860.
 

Darwish T.A.; Smith, A. R. G.; Gentle, I. R.; Burn, P. L.; Luks, E.; Moraes, G.; Gillon, M.; Holden, P. J.; James, M., “Deuteration of Molecules for Neutron Reflectometry on Organic Light-Emitting Diode Thin Films” Tetrahedron Letters, 2012, 53, 931-935.
 

Darwish, T. A.; Evans, R. A.; James, M., Hanley, T. L., “Spiropyran-Amidine: A Molecular Canary for Visual Detection of Carbon Dioxide Gas” Chemistry - A European Journal, 2011, 17, 11399-11404.
 

James, M.; Ciampi, S.; Darwish, T. A.; Hanley, T. L.; Sylvester, S. O.; Gooding, J. J., “Nanoscale Water Condensation on Click-Functionalized Self-Assembled Monolayers”, Langmuir, 2011, 27 (17), 10753-10762.
 

James, M.; Darwish, T. A.; Ciampi, S.; Sylvester, S. O.; Zhang, Z.; Ng, A.; Gooding, J. J.; Hanley, T. L., “Nanoscale Condensation of Water on Self-Assembled Monolayers” Soft Matters, 2011, 7, 5309-5318. 
 

Darwish, T. A.; Evans, R. A.; Hanley, T. L., “Spiropyran, Chromene and Spirooxazine, Mélange Á Trois: Molecular Logic Systems through Selective and Reversible Deactivation of Photochromism Mediated by CO2 Gas”  Dyes and Pigments, 2012, 92, 817-824.
 

Smith, A. R. G.; Ruggles, J. L.; Cavaye, H.; Shaw, P. E.; Darwish, T. A.; James, M.; Gentle, I. R; Burn, P. L., “Investigating Morphology and Stability of Fac-tris(2-phenylpyridyl) iridium(III) Films for OLEDs” Adv. Funct. Mater., 2011, 21, 2225-2231.
 

Darwish, T.A.; Evans, R.A.; James, M.; Malic, N.; Triani, G.; Hanley T.L., “CO2 Triggering and Controlling Orthogonally Multiresponsive Photochromic Systems” J. Am. Chem. Soc., 2010, 132 (31), pp 10748–10755.
 

Ball, G.E.; Brookes, C.M.; Cowan, A.J.; Darwish, T.A.; George, M.W.; Kawanami, H.K.; Portius, P. and Rourke, J.P., "A delicate balance of complexation vs. activation of alkanes interacting with [Re(Cp)(CO)(PF3)] with studies with NMR and time-resolved IR Spectroscopy" Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 6927
 

Lawes, D.J.; Darwish T.A.; Clark, T.; Harper, J.B. and Ball, G.E., "A Rhenium-Cyclohexane Complex with Preferential Binding of Axial C-H Bonds: A Probe into the Relative Ability of C-H, C-D and C-C Bonds as Hyperconjugative Electron Donors?" Angew. Chew. Int. Ed. 2006, 45, 4486
 

Ball, G.E.; Darwish, T.A.; Geftakis, S.; George, M.W.; Lawes, D.J.; Portius, P. and Rouke, J.P., "Characterization of an Organometallic Xenon Complex Using NMR and IR Spectroscopy" Proc. Natl. Acad. Sci. U.S.A. 2005, 102,1853.