Dr Marie-Claude Gregoire

Research Theme Leader
MCG-photo

Profile

Dr Marie-Claude Gregoire is the leader of the Human Health research theme in NSTLI.


She has moved to Australia in 2005 to establish and lead the in vivo molecular imaging platform at ANSTO.


She established and led the LifeSciences division in ANSTO between 2011 and 2016.


Marie-Claude worked in industry for 2 years, and at Mass General Hospital, Boston, for another two years, before being recruited at the Centre National de la Recherche Scientifique (CNRS). She spent 12 years working as a platform and research leader in the field of molecular imaging with nuclear techniques in partnership with the Commissariat des Energies Alternatives (CEA), France.


Her main research interests are in functional exploration of biological pathways with complementary nuclear techniques and multi-modality imaging such as in vivo PET, SPECT, CT, MRI and post mortem imaging. Marie-Claude has produced over 100 journal publications and conference.
 

 

Expertise

  • Quantification methods for in vivo molecular imaging
  • Kinetic modelling of biological interactions measured with PET & SPECT
  • Experiment design and data analysis of functional imaging data

 

 

Honorary affiliations

  • A/Professor at the Faculty of Health Science, University of Sydney
  • Principal Research Scientist, CNRS, France

 

 

Professional networks

  • World Molecular Imaging Society
  • Society for Nuclear Medicine and Molecular Imaging
  • Women in Nuclear
 

Education

  • Masters in Research in Applied Mathematics, University Paris VI, France.
  • PhD in systems control applied to medical imaging from the University of Technology of Compiegne, France.
  • INSEAD Advance Management Program, 2014.

 

 

Selected publications

OSSI-PET: Open-access database of Simulated [11C]Raclopride Scans for the Inveon preclinical PET scanner: Application to the optimization of reconstruction methods for dynamic studies.
Garcia MP, Charil A, Callaghan P, Wimberley C, Busso F, Gregoire MC, Bardies M, Reilhac A. IEEE Trans Med Imaging. 2016 Feb 5

 

Reilhac A, Charil A, Wimberley C, Angelis G, Hamze H, Callaghan P, Garcia MP, Boisson F, Ryder W, Meikle SR, Gregoire MC. 4D PET iterative deconvolution with spatiotemporal regularization for quantitative dynamic PET imaging. Neuroimage. 2015 Sep;118:484-93. doi: 10.1016/j.neuroimage.2015.06.029.


Banati R., MiddletonR., Chan R., Hatty C., Kam W., Quin C., Graeber M., Parmar A., Zahra D., Callaghan P., Fok S., Howell N., Gregoire MC, Szabo A., Pham T., Davis E., Liu GJ. Positron Emission Tomography and Functional Characterisation of a complete PBR/TSPO-knockout. Nat. Commun. 2014 Nov 19;5:5452. doi: 10.1038/ncomms6452


Wimberley CJ, Fischer K, Reilhac A, Pichler BJ, Gregoire MC. A data driven method for estimation of B(avail) and appK(D) using a single injection protocol with [¹¹C]raclopride in the mouse. Neuroimage. 2014 Oct 1;99:365-76. doi: 10.1016/j.neuroimage.2014.05.050.


Vivash, L., Gregoire, M-C., Lau, E. W., Ware, R. E., Binns, D., Roselt, P., Bouilleret, V., Myers, D. E., Cook, M. J., Hicks, R. J., O’Brien, T. J. [18F]-Flumazenil: a novel PET radiotracer for the localisation of drug resistant temporal lobe epilepsy. J Nucl Med. 2013 Aug;54(8):1270-7. doi: 10.2967/jnumed.112.107359.