Dr Anwen Krause-Heuer

Organic Synthetic Chemist
Phone - +61 2 9717 7703
   
Ext_IMG_Krause_ Anwen

Profile

Role at ANSTO
 
Anwen joined the Chemical Deuteration team at the National Deuteration Facility (NDF) as a synthetic chemist in January 2014. Anwen is responsible for synthesis of deuterated molecules and for the running and maintenance of the AB Sciex 4000 QTRAP mass spectrometer, which is an essential tool in the determination of deuteration levels of synthesised molecules.
 
Expertise
 
Anwen has experience in flash chromatography, high pressure liquid chromatography (HPLC), mass spectrometry (MS), nuclear magnetic resonance (NMR).
 
Background
 
Anwen joined ANSTO in 2011 as part of the Graduate Development program and worked in the Radiochemistry group of ANSTO LifeSciences from 2011-2013. Here her research involved the synthesis and radiolabelling of new fluorinated radiopharmaceuticals to investigate diseases including Alzheimer’s, depression and stroke.
 
Qualifications & Achievements
 
  • PhD (University of Western Sydney) - 2015
  • Grad. Cert. Res. Comm.- University of Technology, Sydney, 2010
  • BSc (Hon., Class I)- University of Western Sydney, 2007
  • BSc (Adv. Sci.)- University of Western Sydney, 2006
 
Anwen was awarded a 2013 Science and Industry Endowment Fund – Australian Academy of Science Fellowships to the Lindau Nobel Laureate Meetings. 
 
Anwen was selected by Scientific American as one of the 30 most promising young chemists attending the 63rd Lindau Nobel Laureate Meeting. Anwen was profiled in their series ’30 under 30’.
 
Anwen was awarded the Royal Society of NSW Scholarship in 2012 and the University Medal from the University of Western Sydney in 2008.
 
Anwen is a member of the Royal Australian Chemical Society (MRACI) and Women in Nuclear (WiN).
 
 

Selected publications

D’Alessio, B. Skelton, N. Lengkeek, B. Fraser, A. M. Krause-Heuer, S. Muzzioli, S. Stagni, M. Massi, M. Ogden, Ionophoric properties of a tetra-tetrazole functionalised calix[4]arene. Supramolecular Chemistry, DOI: 10.1080/10610278.2015.1075536 (2015)
 
S. Liang; A. Southon, B. Fraser, A. M. Krause-Heuer, B. Zhang, T. Shoup, R. Lewis, I. Volitakis, Y. Han, I. Greguric, A. Bush, N. Vasdev, Novel fluorinated 8-hydroxyquinoline based metal ionophores for exploring the metal hypothesis of Alzheimer’s disease. ACS Medicinal Chemistry Letters, 6, 1025-1029. DOI: 10.1021/acsmedchemlett.5b00281 (2015)
 
M. Roberts, V. Nguyen, M. Ashford, P. Berghofer, N. Wyatt, A. M. Krause-Heuer, T. Pham, S. Taylor, L. Hogan, C. Jiang, B. Fraser, N. Lengkeek, L. Matestic, M. Gregoire, D. Denoyer, R. Hicks, A. Katsifis, I. Greguric, Synthesis and in vivo evaluation of [123I]melanin-targeted agents. Journal of Medicinal Chemistry, 58, 6214-6224. DOI: 10.1021/acs.jmedchem.5b00777 (2015)
 
M. Medoc, M. Dhilly, L. Matesic, J. Toutain, A. M. Krause-Heuer, J. Delamare, B. Fraser, O. Touzani, L. Barre, I. Greguric, F. Sobrio, In vivo evaluation of radiofluorinated caspases-3,7 inhibitors as radiotracers for apoptosis imaging and comparison with [18F]-ML-10 in a cerebral stroke model in the rat. Molecular Imaging & Biology. DOI: 10.1007/s11307-015-0865-1. (2015)
 
Krause-Heuer, A. M., Yepuri, N., Darwish, T., Holden, P., Mild conditions for deuteration of primary and secondary arylamines for the synthesis of deuterated optoelectronic devices. Molecules, 19, 18604-18617, DOI: 10.3390/molecules191118604 (2014)
 
Fraser. B. H., Hamilton, S. Krause-Heuer, A. M., Wright, P., Greguric, I. Tucker, S., Draffan, A., Fokin , V., Sharpless, K. B., Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B. MedChemComm, 4, 383-386. DOI:10.1039/C2MD20249B (2013)
 
Krause-Heuer, A. M., Howell, N. R., Matesic, L., Dhand, G., Young, E. L., Burgess, L., Jiang, C. D., Lengkeek, N. A., Fookes, C. J. R., Pham, T. Q., Sobrio, F., Greguric, I., Fraser, B. H. A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis. MedChemComm, 4, 347-352. DOI:10.1039/C2MD20300F (2013)
 
Krause-Heuer, A. M., Price, W. S., Aldrich-Wright, J. R., Spectroscopic investigations on the interactions of potent platinum(II) anticancer agents with bovine serum albumin, Journal of Chemical Biology, 5, 105-113. DOI:10.1007/s12154-012-0074-1 (2012) 
 
Krause-Heuer, A. M., Leverett, P., Bolhuis, A., Aldrich-Wright, J. R. Copper(II) and palladium(II) complexes with cytotoxic and antibacterial activity. Australian Journal of Chemistry, 65, 860-873. DOI:10.1071/CH12058 (2012) 
 
Garbutcheon-Singh, K. B., Grant, M. P., Harper, B. W., Krause-Heuer, A. M., Manohar, M., Orkey, N. U., Aldrich-Wright, J. R. Transition metal based anticancer drugs. Current Topics in Medicinal Chemistry, 11, 521-542. DOI:10.2174/156802611794785226 (2011) 
 
Harper, B. W., Krause-Heuer, A. M., Grant, M. P., Manohar, M., Garbutcheon-Singh K. B., Aldrich-Wright, J. R. Advances in platinum chemotherapeutics. Chemistry - A European Journal, 16, 7064-7077. DOI:10.1002/chem.201000148 (2010) 
 
Krause-Heuer, A. M., Grnert, R., Khne, S., Maruszak, M., Wheate, N. J., Le Pevelen, D., Boag, L., Fisher, D. M., Kasparkova, J., Malina, J., Bednarski, P.J., Brabec, V., Aldrich-Wright, J. R. Studies into the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells. Journal of Medicinal Chemistry. 52, 5474-5484. DOI:10.1021/jm9007104 (2009)
 
Krause-Heuer, A. M., Wheate, N. J., Price, W. S., Aldrich-Wright, J. R. Diffusion-based studies on the self-stacking and nanorod formation of platinum(II) intercalators. Chemical Communications, 9, 1210-1212. DOI:10.1039/B820584A (2009) 
 
Krause-Heuer, A. M., Wheate, N. J., Tilby, M. J., Pearson, D. G., Ottley, C. J. , Aldrich-Wright, J. R. Substituted cyclodextrin and calix[4]arene as encapsulatory vehicles for platinum(II)-based DNA intercalators. Inorganic Chemistry, 47, 6880-6888. DOI:10.1021/ic800467c (2008) 
 
Finnie, K. S., Waller, D. J., Perret, F. L., Krause-Heuer, A. M., Lin, H. Q., Hanna J. V., Barb, C. J. Biodegradability of sol-gel silica microparticles for drug delivery. Journal of Sol-Gel Science and Technology, 49, 12-18. DOI:10.1007/s10971-008-1847-4 (2008)
 
Krause-Heuer, A. M., Grant, M. P., Orkey, N., Aldrich-Wright, J. R. Drug delivery devices and targeting agents for platinum(II) anticancer complexes. Australian Journal of Chemistry, 61, 675-681. DOI:10.1071/CH08157 (2008) 
 
Wheate, N. J., Taleb, R ., Krause-Heuer, A. M., Cook, R. L., Wang, S., Higgins, V. J., Aldrich-Wright, J. R. Novel platinum(II)-based anticancer complexes and molecular hosts as their drug delivery vehicles. Dalton Transactions, 43, 5055-5064. DOI:10.1039/B704973K (2007) 
 
Krause-Heuer, A. M., Manohar, M., Garbutcheon-Singh, K. B., Fisher, D. M., Aldrich-Wright, J. R. Chapter 3 The Synthesis of Platinum(II) Intercalators, Metallointercalators, Synthesis and Techniques to Probe Their Interactions with Biomolecules, J. Aldrich-Wright (Ed.), (2010), ISBN 978-3-211-09427-3. 
 
Zheng, G. Krause-Heuer, A. M., Price, W. S. Chapter 7 Pulsed Gradient Spin-Echo NMR, Metallointercalators, Synthesis and Techniques to Probe Their Interactions with Biomolecules, J. Aldrich-Wright (Ed.), (2010), ISBN 978-3-211-09427-3.