Dr Anwen Krause-Heuer

Organic Synthetic Chemist
Phone - +61 2 9717 7703
   
Ext_IMG_Krause_ Anwen

Profile

Role at ANSTO
 
Anwen joined the Chemical Deuteration team at the National Deuteration Facility (NDF) as a synthetic chemist in January 2014. Anwen is responsible for synthesis of deuterated molecules and for the running and maintenance of a number of specialised scientific instruments.
 
Expertise
 
Anwen has experience in organic synthesis, flash chromatography, high pressure liquid chromatography (HPLC), mass spectrometry (MS) and nuclear magnetic resonance (NMR).
 
Background
 
Anwen joined ANSTO in 2011 as part of the Graduate Development program and worked in the Radiochemistry group of ANSTO LifeSciences from 2011-2013. Here her research involved the synthesis and radiolabelling of new fluorinated radiopharmaceuticals to investigate diseases including Alzheimer’s, depression and stroke.
 
Qualifications & Achievements
 
  • PhD (University of Western Sydney) - 2015
  • Grad. Cert. Res. Comm.- University of Technology, Sydney, 2010
  • BSc (Hon., Class I)- University of Western Sydney, 2007
  • BSc (Adv. Sci.)- University of Western Sydney, 2006
 
Anwen was awarded a 2013 Science and Industry Endowment Fund – Australian Academy of Science Fellowships to the Lindau Nobel Laureate Meetings. 
 
Anwen was selected by Scientific American as one of the 30 most promising young chemists attending the 63rd Lindau Nobel Laureate Meeting. Anwen was profiled in their series '30 under 30'.
 
Anwen was awarded the Royal Society of NSW Scholarship in 2012 and the University Medal from the University of Western Sydney in 2008.
 
Anwen is a member of the Royal Australian Chemical Society (MRACI) and Women in Nuclear (WiN).
 
 

Selected publications

For a full list of Anwen's publications please visit her ORCID or Google Scholar pages.
 
A. M. Krause-Heuer, R. Fraser-Spears, J. Dobrowolski, M. Ashford, N. Wyatt, M. Roberts, G. Gould, W. Cheah, C. Ng, M. Bhadbhade, B. Zhang, I. Greguric, N. Wheate, N. Kumar, W. Koek, P. Callaghan, L. Daws, B. Fraser, "Evaluation of the antidepressant therapeutic potential of isocyanine and pseudoisocyanine analogues of the organic cation decynium-22". European Journal of Medicinal Chemistry (2017) 137, 476-487. DOI: 10.1016/j.ejmech.2017.06.011
 
S. Liang; A. Southon, B. Fraser, A. M. Krause-Heuer, B. Zhang, T. Shoup, R. Lewis, I. Volitakis, Y. Han, I. Greguric, A. Bush, N. Vasdev, "Novel fluorinated 8-hydroxyquinoline based metal ionophores for exploring the metal hypothesis of Alzheimer’s disease". ACS Medicinal Chemistry Letters (2015), 6, 1025-1029. DOI: 10.1021/acsmedchemlett.5b00281
 
M. Roberts, V. Nguyen, M. Ashford, P. Berghofer, N. Wyatt, A. M. Krause-Heuer, T. Pham, S. Taylor, L. Hogan, C. Jiang, B. Fraser, N. Lengkeek, L. Matestic, M. Gregoire, D. Denoyer, R. Hicks, A. Katsifis, I. Greguric, "Synthesis and in vivo evaluation of [123I]melanin-targeted agents". Journal of Medicinal Chemistry (2015), 58, 6214-6224. DOI: 10.1021/acs.jmedchem.5b00777
 
A. M. Krause-Heuer,  N. Yepuri, T. Darwish, P. Holden, "Mild conditions for deuteration of primary and secondary arylamines for the synthesis of deuterated optoelectronic devices". Molecules (2014), 19, 18604-18617, DOI: 10.3390/molecules191118604
 
A. M. Krause-Heuer, N. Howell, L. Matesic, G. Dhand, E. Young, L. Burgess, C. Jiang, N. Lengkeek, C. Fookes, T. Pham, F. Sobrio, I. Greguric, B. Fraser, "A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis". MedChemComm (2013), 4, 347-352. DOI: 10.1039/C2MD20300F