Dr Anton Le Brun

Instrument Scientist (Neutron Reflectometry)
Australian Centre for Neutron Scattering
Phone - +61 2 9717 9921
   
Aton Le Brun staff profile

Profile

Role at ANSTO 

 

Anton Le Brun is currently an Instrument Scientist for the SPATZ neutron reflectometer in the Australian Centre for Neutron Scattering. Before this he was a Research Fellow based in the National Deuteration Facility holding an Australian Research Council Development Early Career Researcher Award (ARC DECRA). Other previous positions include Instrument Scientist on the PLATYPUS neutron reflectometer and post-doctoral positions at ANSTO and Diamond Light Source Ltd.


Broad research interests are in studying biological phenomena using neutron scattering techniques, particularly around biological membranes. This includes fabrication and characterisation of biomimetic membranes as platforms for investigating membrane structure and protein-lipid interactions, utilising the properties of membrane proteins and lipids for use in biotechnology, and understanding the interactions between drugs or antibiotics and lipid membranes.

 

Expertise:

• Neutron Reflectometry 
• Membrane Structural Biology
• Protein-lipid interactions
• Surface and interface science
 

Professional networks:

• Australian Society for Biophysics
• Royal Australian Chemical Institute (RACI)
• Australian Neutron Beam Users Group (ANBUG)
 

Education:

• PhD in Biochemistry and Biophysics from the University of Newcastle upon Tyne (UK)
• MRes (with distinction) in Functional Genomics from the University of York (UK)
• BSc(Hons) in Biochemistry from the University of York (UK)

 

 

 

Selected publications

 

Le Brun AP, Haigh CL, Drew SC, James M, Boland MP, Collins SJ: Neutron reflectometry studies define prion protein N-terminal peptide membrane binding. Biophysical Journal, 2014, 107(10):2313-2324. http://dx.doi.org/10.1016/j.bpj.2014.09.027

 

Hatty CR, Le Brun AP, Lake V, Clifton LA, Liu GJ, James M, Banati RB: Investigating the interactions of the 18 kDa translocator protein and its ligand PK11195 in planar lipid bilayers. Biochimica et Biophysica Acta – Biomembranes, 2014, 1838(3):1019-1030. http://dx.doi.org/10.1016/j.bbamem.2013.12.013

 

Le Brun AP, Clifton LA, Halbert CE, Lin B, Meron M, Holden PJ, Lakey JH, Holt SA: Structural Characterisation of a Model Gram-negative Bacterial Surface using Lipopolysaccharides from Rough Strains of Escherichia coli. Biomacromolecules, 2013, 14(6):2014-2022. http://dx.doi.org/10.1021/bm400356m

 

Fernandez DI, Le Brun AP, Whitwell TC, Sani MA, James M, Separovic F: The antimicrobial peptide aurein 1.2 disrupts model membranes via the carpet mechanism. Physical Chemistry Chemical Physics. 2012, 14(45):15739-15751. http://dx.doi.org/10.1039/c2cp43099a

 

Holt SA, Le Brun AP, Majkrzak CF, McGillivray DJ, Heinrich F, Lösche M, Lakey JH: An ion-channel-containing model membrane: structural determination by magnetic contrast neutron reflectometry. Soft Matter 2009, 5(13):2576-2586. http://dx.doi.org/10.1039/b822411k