Dr Guo Jun Liu
Biology Group Leader / Cell Biologist and Electrophysiologist
Role at ANSTO
Dr Guo Jun Liu is the Biology group leader in the Bio-analytics group of ANSTO LifeSciences. Dr Liu examines the impact of radiation on genes, proteins and lipids.
Dr Liu attained his MD at the Jilin University in China and PhD at the Gifu University School of Medicine in Japan. He then accepted a University Postdoctoral Research Fellowship at the University of Western Australia, followed by a University Research Fellowship at the University of Technology Sydney. Before joining ANSTO LifeSciences, he worked as a Senior Research Officer and Senior Research Fellow in the Department of Physiology at the Brain and Mind Research Institute at the University of Sydney, where his field of study was neuroscience. He is currently holding a position as Adjunct Associate Professor at the University of Sydney.
Research interests and areas of expertise
Dr Liu's research interest is mainly in the study of basic biology, using radiation combined with genetic and physiological methods. He is an expert in the areas of cell biology, cell imaging (including calcium imaging), electrophysiology (including patch clamp), and impedance spectrometry.
Qualifications & Achievements
University postdoctoral Research Fellowship from the University of Western Australia;
University Research Fellowship from the University of Technology Sydney
Middleton, R. J., Liu, G-J., Banati, R. B. Guwiyang Wurra - 'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies. Biochemical Society Transactions, 43(4), 553-558 (2015). doi: 10.1042/BST20150039
Banati, R. B., Middleton, R. J., Chan, R., Hatty, C. R., Kam, W. W-Y., Quin, C., Graeber, M. B., Parmar, A., Callaghan, P., Fok, S., Howell, N. R., Gregoire, M-C., Szabo, A. M., Pham, T., Davis, E., Liu, G-J. Positron emission tomography and functional characterization of a complete PBR/TSPO-knockout. Nature Communications, 5, 5452 (2014). doi: 10.1038/ncomms6452.
Buljan, V. A., Holsinger, D. R. M., Hambly, B. D., Kanellis, V., Matar, E., Larkin, X., Liu, G-J., Bohorquez-Florez, J. J., Banati, R. B. Intrinsic synergistic-topological mechanism versus synergistic-topological matrix in microtubule self-organisation. EPJ Nonlinear Biomedical Physics, 2(1), 15 (2014). doi: 10.1140/epjnbp/s40366-014-0015-8
Chan, R. H. Y., Kam W. W-Y., Liu G-J., Zavitsanou K., Banati R. B. Testicular translocator protein expression is differentially altered by synthetic cannabinoid HU210 in adult and adolescent rats. Journal of Addiction Research & Therapy, 5(4), 1000198 (2014). doi: 10.4172/2155-6105.1000198
Hatty, C. R., Le Brun, A. P., Lake, V., Clifton, L. A., Liu, G. J., James, M., Banati, R. B. Investigating the interactions of the 18kDa translocator protein and its ligand PK11195 in planar lipid bilayers Biochimica et Biophysica Acta (BBA) - Biomembranes, 1838(3), 1019–1030 (2014). doi: 10.1016/j.bbamem.2013.12.013
Liu, G. J., Middleton, R.J., Hatty, C.R., Kam W.W.Y., Chan, R., Pham T., Harrison-Brown, M., Dodson, E., Veale, K., Banati, R.B. The 18 kDa translocator protein, microglia and neuroinflammation. Brain Pathology, 24(6), 631–653 (2014). doi: 10.1111/bpa.12196
Werry E. L., Liu, G-J., Lovelace, M. D., Nagarajah, R., Bennett, M. R. (2012) Glutamate potentiates lipopolysaccharide-stimulated interleukin-10 release from neonatal rat spinal cord astrocytes. Neuroscience 207:12-24
Werry, E. L., Liu, G-J., Lovelace, M. D., Nagarajah, R., Hickie, I. B., Bennett, M. R. (2011) Lipopolysaccharide-stimulated interleukin-10 release from neonatal spinal cord microglia is potentiated by glutamate. Neuroscience, 175:93–103.
Liu, G-J., Nagarajah, R., Banati, R. B., Bennett, M. R. (2009). Glutamate induces directed chemotaxis of microglia. European Journal of Neuroscience 29, 1108-1118.
Liu, G-J., Kalous, A., Werry, E. L., Bennett, M. R. (2006) Purine release from spinal cord microglia following elevation of calcium by glutamate. Molecular pharmacology, 70:851-859.
Werry, E. L., Liu, G-J., Bennett, M. R. (2006) Modulation of glutamate-mediated adenosine triphosphate release by substance P in spinal cord astrocytes. Journal of Neurochemistry, 99:926-934.
Liu, G-J., Werry, E. L., Bennett, M. R., (2005). Secretion of ATP from Schwann Cells in Response to Uridine Triphosphate. European Journal of Neuroscience, 21:151-160.
Liu, G-J., Simpson, A. M., Swan, M. A., Tao, C., Tuch, B. E., Crawford, R. M., Jovanovic, A., Martin, D.K. (2003). ATP-sensitive Potassium Channels Induced in Liver Cells after Transfection with Insulin cDNA and the GLUT2 Transporter Regulate Glucose-stimulated Insulin Secretion. FASEB Journal, 17:1682-1684 doi:10.1096/fj.02-0051fje