Dr Madhura Manohar

Organic Synthetic Chemist
Phone - +61 2 9717 7703
   
Madhura Manohar

Profile

Role at ANSTO

Madhura commenced her employment at ANSTO in 2016 as a Synthetic Organic Chemist in the National Deuteration Facility. Her role in this team involves the synthesis of deuterated molecules to assist researchers in exploiting the unique properties offered by deuterium.   

Expertise

Organic synthesis, spectroscopy and chromatography (NMR, MS, HPLC, UV, CD, etc)
 
Background
 
Madhura completed her PhD in Medicinal chemistry in 2016. She synthesised a library of ligands to aid in the understanding of the structural features necessary for the sigma receptor (a receptor involved in a range of neurological disorders). During her time at university she gained experience in various areas of chemistry including organic, inorganic and physical chemistry. 

Qualifications

  • PhD (University of Sydney) - 2016
  • MSc (University of Western Sydney), 2010
  • BSc (Hon) (University of Western Sydney), 2008
  • BSc (Adv. Sci.) (University of Western Sydney), 2007
 

Selected publications

"A systematic exploration of the effects of conformational flexibility and basicity on sigma (σ) receptor binding in a series of substituted diamines" Conroy, T.; Manohar, M.; Gong, Y.; Wilkinson, S.M; Webster, M.; Lieberman, B.P; Banister, S.D; Reekie, T.A; Mach, R.H; Kassiou, M.; Organic and Biomolecular chemistry, 2016, 14(39), 9388-9405  Co-first authorship (equal contribution
 
"Structure–activity relationships of synthetic cannabinoid designer drug RCS-4 and its regioisomers and C4 homologues"  Banister, S. D.; Stuart, J.; Conroy, T.; Longworth, M.; Manohar, M.; Beinat, C.; Wilkinson, S. M.; Kevin, R. C.; Hibbs, D. E.; Glass, M. Forensic Toxicology 2015, 33, 355
 
 “Advances in Platinum Chemotherapeutics” Harper, B.; Krause-Heuer, A.; Grant, M.; Manohar, M.; Garbutcheon-Singh, K. B.; Aldrich-Wright, J.R., Chemistry – A European Journal, 2010, 16, 7064-7077.
 
“Transition Metal Based Anticancer Drugs” Garbutcheon-Singh, K. B., Grant, M.., Harper, B. W., Krause-Heuer, A. M.,  Manohar, M., Orkey, N.U., and Aldrich-Wright, J. R.,  Current Topics in Medicinal Chemistry. 2010