Dr Lidia Matesic

Radiochemist
Phone - +61 2 9717 7337
   
EXT_IMG_MATESIC_LIDIA

Profile

 

Role at ANSTO


Lidia is involved in radiochemistry development research, working primarily with 18F to develop new 18F labelled radiotracers.


Background


Lidia completed a PhD in organic and medicinal chemistry at the University of Wollongong in 2011. Following her degree, she joined ANSTO LifeSciences as a Post-Doctoral Research Fellow before accepting her position as a Radiochemist later in the year.


Research interests and areas of expertise


Lidia’s research interests include 18F radiolabelling using conventional, automated and microfluidic techniques and the development of novel 18F prosthetic groups for incorporation into new radiotracers. Lidia has expertise in 18F radiochemistry, microfluidics, ex vivo radiometabolism studies, organic synthesis and medicinal chemistry.


Qualifications & Achievements

 

PhD (Chemistry), University of Wollongong (2011)
Bachelor of Medicinal Chemistry (Honours), University of Wollongong (2006)
Member of the Royal Australian Chemical Institute (MRACI CChem) and Women in Nuclear
Associate Editor for the journal, Anti-Cancer Agents in Medicinal Chemistry
France-Australia Science Innovation Collaboration Early Career Fellowship (2012)
Royal Society of NSW Scholarship (2010)
AusBiotech-GSK Student Excellence Award – NSW (2009)
Johnson & Johnson Honours Research Prize in Medicinal Chemistry (2007)
Australian Federation of University Women – NSW Inc. Jamieson Award (2007)


 

 

Selected publications


Médoc, M., Dhilly, M., Matesic, L., Toutain, J., Krause-Heuer, A. M., Delamare, J., Fraser, B., Touzani, O., Barre, L., Greguric, I., Sobrio, F. In vivo evaluation of radiofluorinated caspase-3/7 inhibitors as radiotracers for apoptosis imaging and comparison with [18F]ML-10 in a stroke model in the rat. Molecular Imaging and Biology, 18(1), 117-126 (2016). doi: 10.1007/s11307-015-0865-1


Matesic, L., Kallinen, A., Wyatt, N., Pham, T., Greguric, I., Pascali, G. [18F]Fluorination optimisation and the fully automated production of [18F]MEL050 using a microfluidic system. Australian Journal of Chemistry, 68, 69-71 (2015). doi: 10.1071/CH14130

 

Roberts, M. P., Nguyen, V., Ashford, M. E., Berghofer, P., Wyatt, N. A., Krause-Heuer, A. M., Pham, T. Q., Taylor, S. R., Hogan, L., Jiang, C. D., Fraser, B. H., Lengkeek, N. A., Matesic, L., Gregoire, M. C., Denoyer, D., Hicks, R. J and Greguric, I. Synthesis and in vivo evaluation of [123I]melanin-targeted agents. Journal of Medicinal Chemistry, 58(15), 6214-6224 (2015). doi: 10.1021/acs.jmedchem.5b00777

 

Pascali, G., Berton, A., DeSimone, M. R., Wyatt, N., Matesic, L., Greguric, I., Salvadori, P. A. Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis. Applied Radiation and Isotopes, 84, 40-47 (2014). doi: 10.1016/j.apradiso.2013.10.020


Pascali, G., De Simone, M. R., Matesic, L., Greguric, I., Salvadori, P. A. Tolerance of water in microfluidic radiofluorinations: a potential methodological shift? Journal of Flow Chemistry, 4(2), 86-91 (2014). doi: 10.1556/JFC-D-13-00034


Pascali, G., Matesic, L., Collier, T. L., Wyatt, N., Fraser, B. H., Pham, T. Q., Salvadori, P. A., Greguric, I. Optimization of nucleophilic 18F-radiofluorinations using a microfluidic reaction approach. Nature Protocols, 9, 2017-2029 (2014). doi: 10.1038/nprot.2014.137


Krause-Heuer, A. M., Howell, N. R., Matesic, L., Dhand, G., Young, E. L., Burgess, L., Jiang, C. D., Lengkeek, N. A., Fookes, C. J. R., Pham, T. Q., Sobrio, F., Greguric, I., Fraser, B. H. A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis. MedChemComm, 2(4), 347-352 (2013). doi: 10.1039/C2MD20249B


Matesic, L. 18F-radiochemistry using the NanoTek Microfluidic Synthesis System Australian Journal of Chemistry, 66, 1459–1460 (2013). doi: 10.1071/CH13285


Matesic, L., Wyatt, N. A., Fraser, B. H., Roberts, M. P., Pham, T. Q., Greguric, I. Ascertaining the suitability of aryl sulfonyl fluorides for [18F]radiochemistry applications: a systematic investigation using microfluidics. Journal of Organic Chemistry, 78(22), 11262-11270 (2013). doi: 10.1021/jo401759z


Matesic, L., Locke, J. M., Vine, K. L., Ranson, M., Bremner, J. B., Skropeta, D. Synthesis and anti-leukaemic activity of pyrrolo[3,2,1-hi]indole-1,2-diones, pyrrolo[3,2,1-ij]quinoline-1,2-diones and other polycyclic isatin derivatives. Tetrahedron, 68(34), 6810-6819. (2012). doi: 10.1016/j.tet.2012.06.049