Dr Giancarlo Pascali
Role at ANSTO
Giancarlo leads the Radiochemistry team at ANSTO’s Camperdown campus. The group's tasks are related to the synthesis of new radiopharmaceuticals for preclinical imaging studies (mainly in collaboration with the Brain & Mind Centre at the University of Sydney), optimisation of labelling and production procedures, and basic studies on radiochemical development. His workgroup at ANSTO is at the forefront of research in microfluidic chemistry translated to radiopharmaceutical production and basic radiochemical development both in Australia and globally.
Giancarlo completed his PhD in Innovative Materials and Technologies at ISUFI (2004, Lecce, Italy) under the tutoring of P.A. Salvadori (IFC-CNR, Pisa, Italy) and W.C. Eckelman (NIH, Bethesda, MD USA), on the optimization of new radiolabelling approaches utilizing 94mTc, 64Cu and 18F. He was then appointed as responsible for the Toxicology department of BioClinical Analysis for the University of Pisa (2005).
He continued to collaborate on nuclear medicine related projects with the University of Milan, the Milan Policlinico Hospital and Eckert & Ziegler). He joined IFC-CNR in Pisa (2009) as Key Scientist under the EU funded “Radiochemistry On Chip” project on the development of a microfluidic platform for performing radiofluorinations. He was appointed (2011) as the QC responsible for the GMP production site of FDG in IFC-CNR, Pisa. He was involved as Key Scientist in ARISLA funded project (2012) for the development of imaging tracers for ALS disease.
Giancarlo joined ANSTO in January 2013 as the Radiochemistry Team Leader (Camperdown) in the LifeSciences division.
Research interests and areas of expertise
Giancarlo is the author of over 40 scientific publications and is regularly invited speaker at national and international congresses, mainly in the field of nuclear medicine, radiochemistry and microfluidics.
Giancarlo's areas of expertise include: organic synthesis, medicinal chemistry, analytical chemistry, microfluidic chemistry, process automation, radiolabelling utilizing PET and SPECT nuclides, pharmaceutical characterization, imaging techniques.
His current research interests are focused on novel radiofluorination technologies, new 11C chemistry, microfluidic innovation, continuous processing, receptor studies, theranostics optimization, pre-targeting approaches, nanomaterials for drug delivery.
Qualifications & Achievements
PhD (Innovative Materials and Technologies) from the ISUFI-Universitá del Salento (2004) FARE Award (NIH, 2003) Master Degree in Organic Chemistry from the University of Pisa (2001, magna cum laude)
Bianchini, F., Pascali, G., Campo, A., Orecchio, S., Bonsignore, R., Blandino, P., Pietrini, P. Elemental contamination of an open-pit mining area in the Peruvian Andes. International Journal of Environmental Science and Technology, 12(3), 1065-1074 (2015). doi: 10.1007/s13762-013-0493-8
Matesic, L., Kallinen, A., Wyatt, N., Pham, T., Greguric, I., Pascali, G. [18F]Fluorination optimisation and the fully automated production of [18F]MEL050 using a microfluidic system. Australian Journal of Chemistry, 68, 69-71 (2015). doi: 10.1071/CH14130
Pascali, G., Del Carlo, S., Rocchiccioli, S., Signore, G., Saccomanni, G., Manera, C., Macchia, M., Salvadori, P. A. Identification of chemical byproducts in the radiofluorination of structurally complex aryliodonium salts. Journal of Radioanalytical and Nuclear Chemistry, 303, 1021–1027 (2015). doi: 10.1007/s10967-014-3407-4
Saccomanni, G., Pascali, G., Del Carlo, S., Panetta, D., De Simone, M., Bertini, S., Burchielli, S., Di Giacomo, M., Macchia, M., Manera, C., Salvadori, P.A. Design, synthesis and preliminary evaluation of 18F-labelled 1,8-naphthyridin- and quinolin-2-one-3-carboxamide derivatives for PET imaging CB2 cannabinoid receptor. Bioorganic & Medicinal Chemistry Letters, 25(12), 2532–2535 (2015). doi: doi:10.1016/j.bmcl.2015.04.055
Pascali, G., Berton, A., DeSimone, M. R., Wyatt, N., Matesic, L., Greguric, I., Salvadori, P. A. Hardware and software modifications on the Advion NanoTek microfluidic platform to extend flexibility for radiochemical synthesis. Applied Radiation and Isotopes, 84, 40-47 (2014). doi: 10.1016/j.apradiso.2013.10.020
Pascali, G., De Simone, M. R., Matesic, L., Greguric, I., Salvadori, P. A. Tolerance of water in microfluidic radiofluorinations: a potential methodological shift? Journal of Flow Chemistry, 4(2), 86-91 (2014). doi: 10.1556/JFC-D-13-00034
Pascali, G., Matesic, L., Collier, T. L., Wyatt, N., Fraser, B. H., Pham, T. Q., Salvadori, P. A., Greguric, I. Optimization of nucleophilic 18F-radiofluorinations using a microfluidic reaction approach. Nature Protocols, 9, 2017-2029 (2014). doi: 10.1038/nprot.2014.137
Perkins, G., Sheth, R., Greguric, I., Pascali, G. Optimization of [11C]-Raclopride production using a Synthra GPextent system. Current Radiopharmaceuticals, 7(2), 100-6 (2014). doi: 10.2174/1874471007666141021111635
Arima, V., Pascali, G., Lade, O., Kretschmer, H. R., Bernsdorf, I., Hammond, V., Watts, P., De Leonardis, F., Tarn, M. D., Pamme, N., Dittrich, P. S., Cvetkovic, B. Z., Vasovic, N., et al Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals. Lab on a Chip, 13, 2328-2336 (2013). doi: 10.1039/C3LC00055A
Pascali, G., Watts, P., Salvadori, P. A. Microfluidics in radiopharmaceutical chemistry. Nuclear Medicine and Biology, 40(6), 776–787 (2013). doi: 10.1016/j.nucmedbio.2013.04.004
Tarn, M. B., Pascali, G., De Leonardis, F., Watts, P., Salvadori, P. A., Pamme, N. Purification of 2-[18F]fluoro-2-deoxy-d-glucose by on-chip solid-phase extraction. Journal of Chromatography A, 1280, 117-121 (2013). doi: 10.1016/j.chroma.2013.01.032
Watts P., Pascali G., Salvadori P.A. Positron Emission Tomography Radiosynthesis in Microreactors. Journal of Flow Chemistry, 2, 37-42. (2012)
Pascali G., Nannavecchia G., Pitzianti S., Salvadori P.A. Dose-on-demand of diverse 18F-fluorocholine derivatives through a two-step microfluidic approach. Nuclear Medicine and Biology, 38(5), 637-644. (2011)
Zacheo A., Arima V., Pascali G., Salvadori P.A., Zizzari A., Perrone E., De Marco L., Gigli G., Rinaldi R. Radioactivity resistance evaluation of polymeric materials for application in radiopharmaceutical production at microscale. Microfluidics and Nanofluidics, 11(1), 35-44. (2011)
De Leonardis F., Pascali G., Salvadori P.A., Watts P., Pamme N. On-chip pre-concentration and complexation of [18F]fluoride ions via regenerable anion exchange particles for radiochemical synthesis of Positron Emission Tomography tracers. Journal of Chromatography A, 1218(29), 4714-4719. (2011)
Zizzari A., Arima V., Zacheo A., Pascali G., Salvadori P.A., Perrone E., Mangiullo D., Rinaldi R. Fabrication of SU-8 microreactors for radiopharmaceutical production. Microelectronic Engineering, 88(8), 1664-1667. (2011)
Pascali G., Mazzone G., Saccomanni G., Manera C., Salvadori P.A. Microfluidic approach for fast labeling optimization and dose-on-demand implementation. Nuclear Medicine and Biology, 37(5), 547-555. (2010)