Dr Tien  Pham

Radiochemistry Team Leader, Lucas Heights
Phone - +61 2 9717 9515
   
Pham-Tien

Profile

Role at ANSTO

 
Tien leads research tasks in the investigation of novel approaches to the synthetic incorporation of PET and SPECT radioisotopes onto small molecules, peptides and proteins. 
 

Background

 
After completing his PhD in organic chemistry at the University of Wollongong in 2003, Tien accepted a position as a Post Doc at ANSTO. He then continued on as a research scientist. In both roles Tien was responsible for the synthesis and radiolabelling of small molecules, with 18F, 123I, 125I and 99mTc targeting cancer and neurodegenerative diseases. Tien is currently the radiochemistry task leader in ANSTO Lifesciences. 
 

Expertise

 
Tien’s areas of expertise include organic chemistry, medicinal chemistry, radiochemistry, radiolabelling small molecules proteins/peptides, HPLC, PET, SPECT, 18F, 123I, 124I, 125I, 99mTc, 11C. 
 

Qualifications & Achievements

 
  • PhD in Organic Chemistry, at the University of Wollongong (2003)
  • BSc (Hons) in Medicinal Chemistry (1998) 
  • Tien is a member of the Society of Radiopharmaceutical Science.
 
 

Selected publications

Callaghan, P. D., Wimberley, C. A., Rahardjo, G. L., Berghofer, P. J., Pham, T. Q., Jackson, T., Zahra, D., Bourdier, T., Wyatt, N., Greguric, I., Howell, N. R., Siegele, R., Pastuovic, Z., Mattner, F., Loc'h, C., Gregoire, M-C., Katsifis, A. Comparison of in vivo binding properties of the 18 kDa translocator protein (TSPO) ligands [18F]PBR102 and [18F]PBR111 in a model of excitotoxin-induced neuroinflammation. European Journal of Nuclear Medicine and Molecular Imaging, 42(1), 138-151 (2015). doi: 10.1007/s00259-014-2895-3

Matesic, L., Kallinen, A., Wyatt, N., Pham, T., Greguric, I., Pascali, G. [18F]Fluorination optimisation and the fully automated production of [18F]MEL050 using a microfluidic system. Australian Journal of Chemistry, 68, 69-71 (2015). doi: 10.1071/CH14130

Mattner, F., Quinlivan, M., Greguric, I., Pham, T., Liu, X., Jackson, T., Berghofer, P., Fookes, C. J. R., Dikic, B., Gregoire, M-C., Dolle, F., Katsifis, A. Radiosynthesis, in vivo biological evaluation, and imaging of brain lesions with [123I]-CLINME, a new SPECT tracer for the translocator protein. Disease Markers, 2015, 729698 (2015). doi: 10.1155/2015/729698

Roberts, M. P., Nguyen, V., Ashford, M. E., Berghofer, P., Wyatt, N. A., Krause-Heuer, A. M., Pham, T. Q., Taylor, S. R., Hogan, L., Jiang, C. D., Fraser, B. H., Lengkeek, N. A., Matesic, L., Gregoire, M. C., Denoyer, D., Hicks, R. J and Greguric, I. Synthesis and in vivo evaluation of [123I]melanin-targeted agents. Journal of Medicinal Chemistry, 58(15), 6214-6224 (2015). doi: 10.1021/acs.jmedchem.5b00777

Roberts, M. P., Pham, T. Q., Doan, J., Jiang, C. D., Hambley, T. W., Greguric, I., Fraser, B. H. Radiosynthesis and ‘click’ conjugation of ethynyl-4-[18F]fluorobenzene - an improved [18F]synthon for indirect radiolabeling. Journal of Labelled Compounds and Radiopharmaceuticals, 58(13-14), 473-478 (2015). doi: 10.1002/jlcr.3354

Tsartsalis, S., Dumas, N., Tournier, B. B., Pham, T., Moulin-Sallanon, M., Gregoire, M-C., Charnay, Y,. Millet, P. SPECT imaging of glioma with radioiodinated CLINDE: evidence from a mouse GL26 glioma model. European Journal of Nuclear Medicine and Molecular Imaging Research, 5, 9 (2015). doi: 10.1186/s13550-015-0092-4

Ashford, M., Ngyuyen, V. H., Greguric, I., Pham, T., Keller, P., Katsifis, A. Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands. Organic & Biomolecular Chemistry, 12, 783-794 (2014). doi: 10.1039/C3OB42254B

Banati, R. B., Middleton, R. J., Chan, R., Hatty, C. R., Kam, W. W-Y., Quin, C., Graeber, M. B., Parmar, A., Callaghan, P., Fok, S., Howell, N. R., Gregoire, M-C., Szabo, A. M., Pham, T., Davis, E., Liu, G-J. Positron emission tomography and functional characterization of a complete PBR/TSPO-knockout. Nature Communications, 5, 5452 (2014). doi: 10.1038/ncomms6452.

Liu, G. J., Middleton, R.J., Hatty, C.R., Kam W.W.Y., Chan, R., Pham T., Harrison-Brown, M., Dodson, E., Veale, K., Banati, R.B. The 18 kDa translocator protein, microglia and neuroinflammation. Brain Pathology, 24(6), 631–653 (2014). doi: 10.1111/bpa.12196

Pascali, G., Matesic, L., Collier, T. L., Wyatt, N., Fraser, B. H., Pham, T. Q., Salvadori, P. A., Greguric, I. Optimization of nucleophilic 18F-radiofluorinations using a microfluidic reaction approach. Nature Protocols, 9, 2017-2029 (2014). doi: 10.1038/nprot.2014.137

Boisson, F., Wimberley, C., Lehnert, W., Zahra, D., Pham, T., Perkins, G., Hamze, H., Gregoire, M-C., Reilhac, A. NEMA NU 4-2008 Validation and applications of the PET-SORTEO Monte Carlo simulations platform for the geometry of the Inveon PET preclinical scanner. Physics in Medicine and Biology, 58(19), 6749-6763 (2013). doi: 10.1088/0031-9155/58/19/6749

Krause-Heuer, A. M., Howell, N. R., Matesic, L., Dhand, G., Young, E. L., Burgess, L., Jiang, C. D., Lengkeek, N. A., Fookes, C. J. R., Pham, T. Q., Sobrio, F., Greguric, I., Fraser, B. H. A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis. MedChemComm, 2(4), 347-352 (2013). doi: 10.1039/C2MD20249B

Matesic, L., Wyatt, N. A., Fraser, B. H., Roberts, M. P., Pham, T. Q., Greguric, I. Ascertaining the suitability of aryl sulfonyl fluorides for [18F]radiochemistry applications: a systematic investigation using microfluidics. Journal of Organic Chemistry, 78(22), 11262-11270 (2013). doi: 10.1021/jo401759z

Mattner, F., Staykova, M., Berghofer, P., Wong, H-J., Fordham, S., Callaghan, P., Jackson, T., Pham, T., Gregoire, M-C., Zahra, D., Rahardjo, G., Linares, D., Katsifis, A. Central nervous system expression and PET imaging of the translocator protein in relapsing-remitting experimental autoimmune encephalomyelitis. Journal of Nuclear Medicine, 54(2), 291-298 (2013). doi: 10.2967/jnumed.112.108894

Nguyen, V. H., Pham, T., Fookes, C., Berghofer, P., Greguric, I., Arthur, A., Mattner, F., Rahardjo, G., Davis, E., Howell, N., Gregoire, M-C., Katsifis, A., Shepherd, R. Synthesis and biological characterisation of 18F-SIG343 18F-SIG353, novel and high selectivity sigma2 radiotracers, for tumour imaging properties. EJNMMI Research, 3(1), 80 (2013). doi: 10.1186/2191-219X-3-80

Taylor, S. R., Roberts, M. P., Wyatt, N. A., Pham, T. Q., Stark, D., Bourdier, T., Roselt, P., Katsifis, A., Greguric, I. Synthesis and radiosynthesis of a novel PET fluorobenzyl piperazine for melanoma tumour imaging; [18F]MEL054. Australian Journal of Chemistry, 66 (4), 491-499 (2013). doi: 10.1071/CH12489
 
Bourdier, T., Pham, T. Q., Henderson, D., Jackson, T., Lam, P., Izard, M., Katsifis, A. Automated radiosynthesis of [(18)F]PBR111 and [(18)F]PBR102 using the Tracerlab FX(FN) and Tracerlab MX(FDG) module for imaging the peripheral benzodiazepine receptor with PET. Applied radiation and isotopes, 70(1), 176-183. (2012) 
 
Katsifis, A., Loc'h, C., Henderson, D., Bourdier, T., Pham, T., Greguric, I., Lam, P., Callaghan, P., Mattner, F., Eberl, D., Fulham, M. A rapid solid-phase extraction method for measurement of non-metabolised peripheral benzodiazepine receptor ligands, [18F]PBR102 and [18F]PBR111, in rat and primate plasma. Nuclear Medicine and Biology, 38(1), 137-148. (2011) 
 
Greguric, I., Taylor, S. R., Denoyer, D., Ballantyne, P., Berghofer, P., Roselt, P., Pham, T. Q., Mattner, F., Bourdier, T., Neels, O. C., Dorow, D. S., Loc'h, C., Hicks, R. J., Katsifis, A. Discovery of [(18)F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: a melanoma positron emission tomography imaging radiotracer with high tumor to body contrast ratio and rapid renal clearance. Journal of medicinal chemistry, 52(17), 5299-5302. (2009) 
 
Fookes, C. J., Pham, T. Q., Mattner, F., Greguric, I., Loc'h, C., Liu, X., Berghofer, P., Shepherd, R., Gregoire, M-C., Katsifis, A. Synthesis and biological evaluation of substituted [18F]imidazo[1,2-a]pyridines and [18F]pyrazolo[1,5-a]pyrimidines for the study of the peripheral benzodiazepine receptor using positron emission tomography. Journal of medicinal chemistry, 51(13), 3700-12. (2008)
 
Greguric, I., Pham, T. Q., Liu, X., Katsifis, A. Nicotinamide Derivatives for imaging and therapy of melanoma. Provisional Patent No: 2008901989, 2008. 
 
Pham, T. Q., Berghofer, P., Liu, X., Greguric, I., Dikic, B., Ballantyne, P., Mattner, F., Nguyen, V., Loc'h, C., Katsifis, A. Preparation and biologic evaluation of a novel radioiodinated benzylpiperazine, 123I-MEL037, for malignant melanoma. Journal of nuclear medicine. 48(8), 1348-56. (2007) 
 
Pham, T. Q., Greguric, I., Liu, X., Berghofer, P., Ballantyne, P., Chapman, J., Mattner, F., Dikic, B., Jackson, T., Loc'h, C., Katsifis, A. Synthesis and evaluation of novel radioiodinated benzamides for malignant melanoma. Journal of medicinal chemistry, 50(15), 3561-72. (2007)
Katsifis, A., Fookes, C. J. R., Pham, T. Q., Greguric. I., Mattner, F. Fluorinated ligands for targeting peripheral benzodiazepine receptors. Patent No: 2006904617, 2006.