Tailored solutions

 

Radiotracer characterisation
 

Analysis of radiotracer uptake (in vivo PET/SPECT, biodistribution)
 

Radiotracer uptake is often expressed in percent of injected dose per weight of wet tissue (%ID/g). In in vivo PET/SPECT studies, Volumes or Regions of Interest (VOIs/ROIs) are drawn and regional activity data (Bq/cm3) is extracted from these VOIs/ROIs. The Time-Activity Curves are derived from the calculated data using image analysis software.


Kinetic modelling may be involved if sophisticated data is required for compartmental uptakes or clearance. In biodistribution studies, %ID/g values are calculated to express the uptakes of radiotracers in organs of interest. Ratios of target:non-target or organ:background uptakes are often calculated to serve as indications of radiotracer selectivity/specificity and clearance.
 

Contact scientist: Vu Nguyen
 

Radioligand stability studies
 

In vitro radioligand stability studies are often conducted in physiological solutions or body fluids (plasma/blood), mimicking physiological conditions to establish the tracer stability over time. In vivo radioligand stability studies are performed to examine the unchanged/changed fractions of the tracers in relevant organs or tissues, often the targets of the tracer. Both techniques involve activity extraction and/or analytical methodologies such as radio-HPLC, radio-TLC or appropriate chromatography methods.
 

Contact scientists: Ivan Greguric (in vitro and in vivo stability), Vu Nguyen (in vivo stability)  


Precision irradiation

 

ANSTO's Radiation Technology group operates 60Co irradiators for small scale irradiation studies to a wide range of doses and dose rates. Our unique capabilities enable us to accurately deliver high doses of radiation with a precision not achievable in industrial-scale irradiators. Controlled dose rates and temperatures allow users to test ideas, develop applications and perform irradiations under non-standard conditions.

 

The range of applications provided by our service include:

 

 

Crop protection

 

The Sterile Insect Technique is the primary pest management program to contain and eradicate Queensland fruit fly (Q-fly) outbreaks. SIT is the only alternative to cover-spray applications of toxic pesticides when eradication is required. In Australia, this program was developed in collaboration with ANSTO in the 1980’s. ANSTO’s Radiation Technology group continues to irradiate these insects for the Tri-State SIT program (NSW, VIC and SA) to protect citrus, stone fruit, pome fruit, grapes and other crops.

 

Bone & tissue grafts

While radiation is commonly used to sterilise bone grafts, high doses are detrimental to bone and soft tissues. ANSTO's Radiation Technology capabilities provides researchers with the ability to test ideas such as the bio-compatibility and structural integrity of bone grafts over a range of radiation doses with the aim of ensuring reliability for use.

 

Contact scientists: Justin Davies and Connie Banos