Ms Paula Berghofer
Staff Profile
Role at ANSTO
As a member of the Imaging team, Paula investigates the properties of novel radiopharmaceuticals in living systems to evaluate their suitability as diagnostic or therapeutic tools for a specific disease states. Additionally, as LifeSciences Safety Officer she promotes and co-ordinates safety activities and processes accompanied by safety fundamentals for the division. Paula also engages in the LifeSciences product optimisation and commercialisation arm.
Background
After completing her undergraduate degree, Paula joined LifeSciences (at that time known as the Radiopharmaceutical Research Institute) in 2003 as part of the pharmacology team evaluating new drugs for various diseases.
Research interests and areas of expertise
Paula’s expertise lies in small animal imaging and cancer-targeting novel radiopharmaceuticals while her current interest is the translation of research outcomes into business opportunities.
Qualifications & Achievements
Hons in Biology at the University of Wollongong
BSc (Biomedical) at the University of Western Sydney
Publications
Mattner, F., Staykova, M., Berghofer, P., Wong, H-J., Fordham, S., Callaghan, P., Jackson, T., Pham, T., Gregoire, M-C., Zahra, D., Rahardjo, G., Linares, D., Katsifis, A. Central nervous system expression and PET imaging of the translocator protein in relapsing-remitting experimental autoimmune encephalomyelitis. Journal of Nuclear Medicine 2012
Ranson, M., Berghofer, P., Vine, K. L., Greguric, I., Shepherd, R., Katsifis, A. Different radiolabelling methods alter the pharmacokinetic and biodistribution properties of Plasminogen Activator Inhibitor Type 2 (PAI-2) forms. Nuclear Medicine and Biology 2012 39 (6) 833-9.
Mattner, F., Staykova, M., Callaghan, P., Berghofer, P., Ballantyne, P., Gregoire, M. C., Fordham, S., Pham, T., Rahardjo, G., Jackson, T., Linares, D., Katsifis, A. Assessment of neuroinflammation in transferred EAE via a translocator protein ligand. In R. Weissert (Ed.), Experimental Autoimmune Encephalomyelitis - Models, Disease Biology and Experimental Therapy (chapter 3). Rijeka, Croatia: InTech (2012). Book chapter
Dedeurwaerdere, S., Callaghan, P. D., Pham, T., L Rahardjo, G. L., Amhaoul, H., Berghofer, P., Quinlivan, M., Mattner, M., Loch, C., Katsifis, A., Gregoire, M-C. PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy. European Journal of Nuclear Medicine and Molecular Imaging 2012
Berghofer, P., Ranson, M., Vine, K., Greguric, I., Shepherd, R., Katsifis, A. In vivo pharmacokinetics of radioiodinated urokinase plasminogen activator (uPA) inhibitors for imaging metastatic cancer. Internal Medicine Journal, 41(s3), 9. (2011)
Amy R Wyatt, Justin J Yerbury, Paula Berghofer, Ivan Greguric, Andrew Katsifis, Christopher M Dobson, Mark R Wilson. Clusterin facilitates in vivo clearance of extracellular misfolded proteins. Cellular and molecular life sciences : CMLS. 2011 Apr 20:
Filomena Mattner, David Linares Bandin, Maria Staykova, Paula Berghofer, Marie Claude Gregoire, Patrice Ballantyne, Mitchell Quinlivan, Susan Fordham, Tien Pham, David O Willenborg, Andrew Katsifis. Evaluation of [(123)I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation. European journal of nuclear medicine and molecular imaging. 2011 Apr 12:
Thomas Bourdier, Rachael Shepherd, Paula Berghofer, Timothy Jackson, Christopher J R Fookes, Delphine Denoyer, Donna S Dorow, Ivan Greguric, Marie-Claude Gregoire, Rodney J Hicks, Andrew Katsifis. Radiosynthesis and biological evaluation of L- and D-S-(3-[18F]fluoropropyl)homocysteine for tumor imaging using positron emission tomography. Journal of medicinal chemistry. 2011 Mar 24;54(6): 1860-70
Di Xiao, David Zahra, Pierrick Bourgeat, Paula Berghofer, Oscar Acosta Tamayo, Catriona Wimberley, Marie Claude Gregoire, Olivier Salvado, "An improved 3D shape context based non-rigid registration method and its application to small animal skeletons registration", Computerized Medical Imaging and Graphics, 34(4), 321-332, 2010.
Di Xiao, David Zahra, Pierrick Bourgeat, Paula Berghofer, Oscar Acosta Tamayo, Catriona Wimberley, Marie-Claude Gregoire, and Olivier Salvado, "An improved 3D shape context registration method for non-rigid surface registration", in Proc. SPIE, Medical Imaging 2010, Vol. 7623, pages 76232Q, 2010.
Di Xiao, David Zahra, Pierrick Bourgeat, Paula Berghofer, Oscar Acosta Tamayo, Catriona Wimberley, Marie Claude Gregoire, and Olivier Salvado, "A non-rigid registration method for mouse whole body skeleton registration", in Proc. SPIE, Medical Imaging 2010, Vol. 7626, pages 76261N, 2010.
Greguric I, Taylor SR, Denoyer D, Ballantyne P, Berghofer P, Roselt P, Pham TQ, Mattner F, Bourdier T, Neels OC, Dorow DS, Loch C, Hicks RJ, Katsifis A. Discovery of [18F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance. J Med Chem. (2009)
Fookes CJR, Pham TQ, Mattner F, Greguric I, Loch C, Liu X, Berghofer P, Shepherd R, Gregoire M-C, Katsifis A. Synthesis and Biological Evaluation of Substituted [18F]Imidazo[1,2-a]pyridines and [18F]Pyrazolo[1,5-a]pyrimidines for the Study of the Peripheral Benzodiazepine Receptor Using Positron Emission Tomography. J Med Chem. 2008;51(13):3700-3712.
Liu X, Pham TQ, Berghofer P, Chapman J, Greguric I, Mitchell P, Mattner F, Loch C, Katsifis. A. Synthesis and evaluation of novel radioiodinated nicotinamides for malignant melanoma. Nucl Med Biol. 2008;35(7):769-781.
Pham TQ, Berghofer P, Liu X, et al. Preparation and Biologic Evaluation of a Novel Radioiodinated Benzylpiperazine, 123I-MEL037, for Malignant Melanoma. J Nucl Med. 2007;48(8):1348-1356.
Pham TQ, Greguric I, Liu X, Berghofer P, Ballantyne P, Chapman J, Mattner F, Dikic B, Jackson T, Loch C, Katsifis A, Synthesis and Evaluation of Novel Radioiodinated Benzamides for Malignant Melanoma. J Med Chem. 2007;50(15):3561-3572.