International Year of Crystallography

Dr Vu Nguyen

Radiopharmacology Interface/Radiotracer Evaluation Co-ordinator
ANSTO Life Sciences
Phone - +61 2 9717 9081
Vu Nguyen

Staff Profile

 

Role at ANSTO


Dr Nguyen applies knowledge in pharmacodynamics and pharmacokinetics in radiotracer evaluation at LifeSciences for their various aspects including tumour and brain imaging. He also facilitates further radiopharmacological research for potential tracers, to research collaborators or commercial entities. 

 

Background


Dr Nguyen studied Pharmacy and obtained a Bachelor Degree of Pharmacy at the University of South Australia (Adelaide). After graduation, he joined Faulding Pharmaceuticals (Adelaide) who specialises in sustained release antibiotics, NSAIDs and narcotic analgesics until 1991.

 

Since joining ANSTO, Vu had been participating in various projects including cancer imaging, neuroimaging, clinical trials of radiopharmaceuticals. He had been Principal Investigators for a number of joint projects with business partners including Agen Biomedicals Ltd in the contract research project “Stability and Safety Investigations of Thromboview®, a diagnostic agent for the imaging of Pulmonary Embolism and Deep Vein Thrombosis” and The Wollongong University/Newcastle University in “Antagonists of Corticotropin Releasing Hormone as therapeutic agents for the prevention of premature birth in humans”.

 

Research Interests and Areas of Expertise


Drug evaluation (pharmacodynamics, pharmacokinetics, clinical pharmacy, sigma receptor research, cannabinoid research, second messengers and their pathways)

 

Qualifications and Achievements

 

  • PhD. (Pharmacology) - Sydney University
  • Grad. Cert. (Radiopharmacy Practice) – Monash University/The Victorian College of Pharmacy
  • BPharm. – The University of South Australia

 

Professional affiliations

 

  • Reviewer and Editor for Quarterly J. Nucl. Med. & Mol. Imaging (Pharmacology Section)
  • Member of The Australian College of Pharmacy


 

 

Selected Publications

Nguyen VH, Wang H, Verdurand M, Zavitsanou K (2012) Differential Treatment Regimen-Related Effects of HU210 on CB1 and D2-Like Receptor Functionality in the Rat Basal Ganglia, Pharmacology 89(1-2), 64-73.

Nguyen VH, Verdurand M, Dedeurwaedere S, Wang H, Zahra D, Gregoire M-C, Zavitsanou K (2012) Increased Brain Metabolism after Acute Administration of the Synthetic Cannabinoid HU210: A Small Animal PET Imaging Study with [18F]FDG Brain Res Bull 87(2-3), 172-179.

Verdurand M, Nguyen VH, Stark D, Zahra D, Gregoire M-C, Greguric I, Zavitsanou K (2011) Comparison of cannabinoid CB1 receptor binding in adolescent and adult rats: A Positron Emission Tomography study using [18F]MK-9470, Int J Mol Imaging 2011, 1-11.

Zavitsanou K, Wang H, Dalton VS, Nguyen VH (2010) annabinoid administration increases 5HT1A receptor binding and mRNA in the hippocampus of adult but not adolescent rats, Neurosci 169, 315-324.

Zavitsanou K, Nguyen VH, Newell K, Ballantyne P, Huang X-F (2008) Rapid cortico-limbic alterations in AMPA receptor densities after administration of PCP: Implications for schizophrenia, J. Chem. Neuroanatomy 36, 71-76.

Pham T, Berghofer P, Liu X, Greguric I, Dikic B, Ballantyne P, Mattner F, Nguyen V, Loch C, Katsifis A (2007) Preparation and Biological Evaluation of a Novel Radioiodinated Benzyl-Piperazine, 123I-MEL037, for Malignant Melanoma, J. Nucl. Med. 48(8), 1348-1356.

Zavitsanou K, Nguyen VH, Greguric I, Chapman J, Ballantyne P, Katsifis A (2007) Detection of apoptotic cell death in the thymus of dexamethasone treated rats using [123I]Annexin V and in situ oligonucleotide ligation, J. Mol. Hist. 38, 313-319.

Zavitsanou K, Nguyen VH, Salvadori P, Smith S (2007) Radiopharmacy and Radiopharmaceuticals: 2007 Update, Q J. Nucl. Med. & Mol. Imaging 51, 3-5. Zavitsanou K, Nguyen VH, Han M, Huang XF (2007) Effects of typical and atypical antipsychotic drugs on rat brain muscarinic receptors, Neurochem Res. 32, 525-532.

Lin HQ, Nguyen VH, Ballantyne P, Berghofer P, Chapman J, Katsifis A, Barbe C, Larkin M, Burch WM (2006) Application of a Tumour Calculation Method to Biodistribution Studies with the Mouse B16F10 Lung Metastasis Model. Acta Pharmacologica Sinica 27 Suppl 1, 215.

Nguyen VH, Mardon K, Kassiou M, Christie MJ (1999) In-vitro and in-vivo characterisations of [3H]ANSTO-14 binding to the ?1 binding sites, Nucl. Med. & Biol. 26(2), 209-215.

Nguyen VH, Ingram SL, Kassiou M, Christie MJ (1998) ??-Binding site ligands inhibit potassium currents in rat locus coeruleus neurons in vitro, Eur. J. Pharmacol. 361, 157-163.

Nguyen VH, Kassiou M, Johnston GAR, Christie MJ (1996) Comparison of binding parameters of ?1 and ?2 binding sites in rat and guinea pig brain membranes: Novel subtype-selective trishomocubanes, Eur. J. Pharmacol. 311, 233-240.

Kassiou M, Nguyen VH, Knott R, Christie MJ, Hambley TW (1996) Trishomocubanes, a new class of selective and high affinity ligands for the sigma binding sites, Biorg. Med. Chem. Letters 6(6), 595-600.