Dr Rachael Shepherd
Cell Biologist
ANSTO Life Sciences
Staff Profile
Role at ANSTO
Rachael works with in vitro analysis of novel compounds and radiotracers, developing in vitro techniques, and identifying and analysing new radiotracer targets.
Background
Before joining LifeSciences in 2005, Rachael completed her PhD at the University of Sydney in which she investigated the role of apoptosis in the pathophysiology of mitochondrial disorders. Rachael's primary role within LifeSciences is to investigate novel radiotracers or potential targets using in vitro techniques.
Research interests and areas of expertise
Rachael’s areas of expertise include cell culture, immunofluorescence assays, histology, radioligand binding assays, radiotracer cell uptake assays, and in vivo radiotracer analysis.
Qualifications & Achievements
PhD at the University of Sydney (2007)
Publications
Denoyer, D., Kirby, L., Waldeck, K., Roselt, P., Neels, O. C., Bourdier, T., Shepherd, R., Katsifis, A., Hicks, R. J. Preclinical characterization of 18F-D-FPHCys, a new amino acid-based PET tracer. European Journal of Nuclear Medicine and Molecular Imaging. (in press, 2012)
Bourdier, T., Shepherd, R., Berghofer, P., Jackson, T., Fookes, C. J., Denoyer, D., Dorow, D., Greguric, I., Gregoire, M-C., Hicks, R. J., Katsifis, A. Radiosynthesis and biological evaluation of L and D S-(3-[18F]Fluoropropyl)-homocysteine for tumor imaging using positron emission tomography. Journal of Medicinal Chemistry, 54(6), 1860-1870. (2011)
Fookes, C. J. R., Pham, T. Q., Mattner, F., Greguric, I., Loc’h, C., Liu, X., Berghofer, P., Shepherd, R., Gregoire, M-C., Katsifis, A. Synthesis and biological rvaluation of substituted [18F]Imidazo[1,2-a]pyridines and [18F]Pyrazolo[1,5-a]pyrimidines for the study of the Peripheral Benzodiazepine Receptor using Positron Emission Tomography. Journal of Medicinal Chemistry, 51(13), 3700-3712. (2008)