Dr Anna Sokolova

Instrument Scientist
Bragg Institute
Phone - +61 2 +61 2 9717 7288
+61 429 074 526
Dr Anna Sokolova

Profile

Role at ANSTO

 

Dr Anna Sokolova is a Project Leader for the design, construction and commissioning of BILBY, the new time-of-flight small-angle neutron scattering instrument at the Bragg Institute. Anna Sokolova is a biophysicist from Institute of Crystallography of Russian Academy of Science (small-angle scattering laboratory). During her PhD and the following several years, she extensively worked in the European Molecular Biology Laboratory (EMBL, Hamburg outstation c/o Deutsche Electronen Synchrotron).

 

She has a Masters in Physics/Biophysics from Physical Department of Moscow State University and a PhD in Condensed Matter Physics at the Institute of Crystallography (Moscow, Russia). Both were focused on development of new methods for small angle scattering data analysis and interpretation as well as on SAXS technique implementation to proteins structure studies.

 

From 2007 to 2009 Anna worked as a Postdoctoral Fellow in Food Science Project Group at the Bragg Institute, ANSTO.

 

Anna’s main scientific interest is the complex biology related structures small angle scattering data collection, processing and interpretation. Also Anna has wide experience in programming (Fortran; HTML, and PHP for web-applications development) and mathematical methods in structural research. She also practised at the Institute of Bioorganic Chemistry (Moscow, Russia) in basic biochemistry technics for protein sample preparation.

 

Qualifications & Achievements

 

November 2006
Academia Europea Prize for young scientist in physics

April, 2004
PhD defended in the field of physics and mathematics.

December, 2003
First diploma in contest of scientific works of young scientists in the Institue of Crystallography RAS

January, 2000
MSc in physics (diploma cum laude and the golden medal for excellent graduation), Physical department, Chair of Biophysics of the Moscow State University

 

Expertise

2016-2019

Member of the Scientific and Technical Advisory Panel for Small Angle Neutron Scattering for the European Spallation Source

 

Selected publications

Sokolova A.; Christoforidis J.; Eltobaji A.; Barnes J.; Darmann F.; Whitten A.E.; de Campo L. BILBY: Time-of-Flight Small Angle Scattering Instrument Neutron News, 2016, 27(2): 9-13

 

Wood K.; Jeffries C.M.; Knott R.B.; Sokolova A.V.; Jacques D.A.; Duff A.P. Exploring the structure of biological macromolecules in solution using Quokka, the small angle neutron scattering instrument, at ANSTO Nuclear instruments & methods in physics research, Section A - Accelerators Spectrometers Detectors and Associated Equipment, 2015, 798: 44-51

 

Kikhney A.G.; Panjkovich A.; Sokolova A.; Svergun D.I. DARA: a web server for rapid search pf structural neighbours using solution small angle X-ray scattering data. Bioinformatics, 2015, 32(4): 616-618

 

Pham C.L.L.; Kirby N.; Wood K.; Ryan T.; Roberts B.; Sokolova A.V.; Barnham K.J.; Masters C.L.; Knott R.B.; Cappai R.; Curtain C.C.; Rekas A. Guanidine hydrochloride denaturation of dopamine-induced alpha-synuclein oligomers: A small-angle X-ray scattering study. PROTEINS: Structure, Function and Bioinformatics, 2014, 82(1): 10-21

 

Pham C.L.L.; Kirby N.; Wood K.; Ryan T.; Roberts B.; Sokolova A.V.; Barnham K.J.; Masters C.L.; Knott R.B.; Cappai R.; Curtain C.C.; Rekas A. Guanidine hydrochloride denaturation of dopamine-induced alpha-synuclein oligomers: A small-angle X-ray scattering study. PROTEINS: Structure, Function and Bioinformatics, 2014, 82(1): 10-21

 

Jiang L.; Phang J.M.; Yu J.; Harrop S.J.; Sokolova A.V.; Duff A.P.; Wilk K.E.; Alkhamici H.; Breit S.N.; Valenzuela S.M.; Brown L.J.l Curmi P.M. CLIC protein, ezrin, radixin, moesin and the copuling of membranes to the actic cytoskeletons: A smoking gun? Biochim Biophys Acta, 2014. February,  1838 (2): 643-657

 

Sokolova A.V.; Huang S.-L.; Duff A.; Gilbert E.P.; Li W.-H. Correlation of thermostability and confirmational changes of catechol 2,3-dioxygenases from two disparate micro-organisms, Biophysical Chemistry, 2013, 180-181: 145-152

 

Sokolova A., Kealley C.S., Hanley T., Rekas A., Gilbert E.P. Small-Angle X-ray Scattering Study of the Effect of pH and Salts on 11S Soy Glycinin in the Freeze-Dried Powder and Solution States, J. Agric. Food Chem., 2010, 58(2): 967-974

 

Kealley C.; Sokolova A. V.; Kearley G. J.; Kemner E.; Russina M.; Faraone A.; Hamilton W. A.; Gilbert E. P. Dynamical transition in a large globular protein: macroscopic properties and glass transition, Biochimica et Biophysica Acta - Proteins and Proteomics. 2010. January, 1804(1): 34-40

 

Rekas A.; Knott R.; Sokolova A.V.; Barnham K.J.; Perez K.A.; Masters C.L.; Drew S.C.; Cappai R.; Curtain C.C.; Pham C.L.L. The structure of dopamine induced alpha-synuclein oligomer, European Biophysical Journal, 2010, 39(10):1407-1419

 

Volkov V.V.; Lapuk V.A.; Shtykova E.V.; Stepina N.D.; Dembo K.A.; Sokolova A.V.; Amarantov S.V.; Timofeev V.P.; Ziganshin R.K.; Varlamova E.Y. Structural features of Fab fragments of theumatoid factor IgM-RF in solution, Crystallography Reports. 2008, 53(3): 466-473

 

Sokolova A. V., Kreplak L, Svergun D. I., Wedig T., Herrmann H., Aebi U., and Strelkov S. V. Monitoring intermediate filament assembly by small-angle x-ray scattering reveals the molecular architecture of assembly intermediates, PNAS October 31, 2006. 103 no. 44: 16206-16211
 


W. A. Stanley, A. Sokolova, A. Brown, D. T. Clarke, M. Wilmanns and D. I. Svergun Synergistic use of synchrotron radiation techniques for biological samples in solution: a case study on protein-ligand recognition by the peroxisomal import receptor Pex5p, J. Synchrotron Rad. 2004. 11: 490-496
 


Konarev P. V., Volkov V. V., Sokolova A. V., Koch M. H. J. and Svergun D. I. PRIMUS: a Windows PC-based system for small-angle scattering data analysis, J.Appl.Cryst. 2003. 36: 1277-1282
 


Sokolova A.V., Volkov V. V. and Svergun D. I. Prototype of a database for rapid protein classification based on solution scattering data, J.Appl.Cryst. 2003. 36: 865-868
 


Sokolova A. V., Malfois M., Caldentey J., Svergun D. I., Koch M. H. J., Bamford D. H. and Tuma R. Solution structure of bacteriophage PRD1 vertex complex, J. Biol.Chem. 2001, 49, Issue of December, 276: 46187-46195