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Deuteration Publications


  1. Controlling Phase and Rheological Behaviours of Hexagonal Lyotropic Liquid Crystalline Templates for Nanostructural Administration and Retention.
    Wang, G., Garvey, C. J., Gu, S., Gao, W., O'Dell, L. A., Krause-Heuer, A. M., Darwish, T. A., Zhigunov, A., Tong, X., Kong, L.
    Journal of Colloid and Interface Science.
  2. Lipid bilayer degradation induced by SARS-CoV-2 spike protein as revealed by neutron reflectometry.
    Luchini, A., Micciulla, S., Corucci, G., Batchu, K. C., Santamaria, A., Laux, V., Darwish, T., Russell, R. A., Thepaut, M., Bally, I., Fieschi, F. & Fragneto, G.
    Scientific Reports, 11, 14867.
  3. H/D Isotope Effects in Keto-Enol Tautomerism of β-Dicarbonyl Compounds —Importance of Nuclear Quantum Effects of Hydrogen Nuclei—.
    Udagawa, T., Murphy, R. B., Darwish, T. A., Tachikawa, M. & Mori, S.
    Bulletin of the Chemical Society of Japan, 94, 1954-1962.
  4. Deuterated Bacterial Cellulose Dissolution in Ionic Liquids.
    Raghuwanshi, V. S., Cohen, Y., Garnier, G., Garvey, C. J. & Garnier, G.
  5. Diffusion in Organic Film Stacks Containing Solution-Processed Phosphorescent Poly(dendrimer) Dopants.
    McEwan, J. A., Clulow, A. J., Nelson, A., Krause-Heuer, A. M., Jansen-van Vuuren, R. D., Burn, P. L. & Gentle, I. R.
    ACS Applied Materials & Interfaces, 13, 30910-30920.
  6. Measuring the Magnetic Field Amplitude of rf Radiation by the Quasistatic Magnetic Field Effect in Organic Light-Emitting Diodes.
    Grünbaum, T., Bange, S., Jiang, W., Leung, A. E., Darwish, T. A., Burn, P. L. & Lupton, J. M.
    Physical Review Applied, 15, 064001.
  7. Kinetic isotope effects and synthetic strategies for deuterated carbon-11 and fluorine-18 labelled PET radiopharmaceuticals.
    Klenner, M. A., Pascali, G., Fraser, B. H. & Darwish, T. A.
    Nuclear Medicine and Biology, 96-97, 112-147.
  8. ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition.
    Waldie, S., Sebastiani, F., Moulin, M., Del Giudice, R., Paracini, N., Roosen-Runge, F., Gerelli, Y., Prevost, S., Voss, J. C., Darwish, T. A., Yepuri, N., Pichler, H., Maric, S., Forsyth, V. T., Haertlein, M. & Cárdenas, M.
    Frontiers in Chemistry, 9.
  9. Targeted delivery of LM22A-4 by cubosomes protects retinal ganglion cells in an experimental glaucoma model.
    Ding, Y., Chow, S. H., Chen, J., Brun, A. P. L., Wu, C.-M., Duff, A. P., Wang, Y., Song, J., Wang, J.-H., Wong, V. H. Y., Zhao, D., Nishimura, T., Lee, T.-H., Conn, C. E., Hsu, H.-Y., Bui, B. V., Liu, G.-S. & Shen, H.-H.
    Acta Biomaterialia.
  10. Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles.
    Sebastiani, F., Yanez Arteta, M., Lerche, M., Porcar, L., Lang, C., Bragg, R. A., Elmore, C. S., Krishnamurthy, V. R., Russell, R. A., Darwish, T., Pichler, H., Waldie, S., Moulin, M., Haertlein, M., Forsyth, V. T., Lindfors, L. & Cárdenas, M.
    ACS Nano.
  11. Substrate-dependent arrangements of the subunits of the BAM complex determined by neutron reflectometry.
    Chen, X., Ding, Y., Bamert, R. S., Le Brun, A. P., Duff, A. P., Wu, C.-M., Hsu, H.-Y., Shiota, T., Lithgow, T. & Shen, H.-H.
    Biochimica et Biophysica Acta (BBA) - Biomembranes, 183587.
  12. Membrane Protein Structures in Lipid Bilayers; Small-Angle Neutron Scattering With Contrast-Matched Bicontinuous Cubic Phases.
    Conn, C. E., de Campo, L., Whitten, A. E., Garvey, C. J., Krause-Heuer, A. M. & van 't Hag, L.
    Frontiers in Chemistry, 8.
  13. Interactions of Non-steroidal Anti-inflammatory Drugs and Their Bismuth Analogues (BiNSAIDs) with Biological Membrane Mimics at Physiological
    Oliver, T. E., Piantavigna, S., Andrews, P. C., Holt, S. A. & Dillon, C. T.
  14. Floquet spin states in OLEDs.
    Jamali, S., Mkhitaryan, V. V., Malissa, H., Nahlawi, A., Popli, H., Grünbaum, T., Bange, S., Milster, S., Stoltzfus, D. M., Leung, A. E., Darwish, T. A., Burn, P. L., Lupton, J. M. & Boehme, C.
    Nature Communications, 12, 465.
  15. Direct localization of detergents and bacteriorhodopsin in the lipidic cubic phase by small-angle neutron scattering.
    Cleveland IV, T., Blick, E., Krueger, S., Leung, A., Darwish, T. & Butler, P.
    IUCrJ, 8.
  16. Metal Catalyzed H/D Exchange Methods Using D2O as a Deuterium Source: A Comparative Study in Different Sealed Devices.
    Akutsu-Suyama, K., Park, K., Takakura, R., Tamura, K., Cagnes, M., Darwish, T. A., Yamada, T., Sawama, Y. & Sajiki, H. 2021.
    Proceedings of the 3rd J-PARC Symposium (J-PARC2019).
    Journal of the Physical Society of Japan.


  1. The Antifungal Mechanism of Amphotericin B Elucidated in Ergosterol and Cholesterol-Containing Membranes Using Neutron Reflectometry.
    Delhom, R., Nelson, A., Laux, V., Haertlein, M., Knecht, W., Fragneto, G. & Wacklin-Knecht, H. P.
    Nanomaterials, 10, 2439. (2020)

  2. Using Humidity to Control the Morphology and Properties of Electrospun BioPEGylated Polyhydroxybutyrate Scaffolds.
    Foster, L. J. R., Chan, R. T. H., Russell, R. A. & Holden, P. J.
    ACS Omega, 5, 26476-26485.

  3. The effect of deuteration on the keto-enol equilibrium and photostability of the sunscreen agent avobenzone.

  4. Murphy, R., Staton, J., Rawal, A. & Darwish, T. A.
    Photochemical & Photobiological Sciences.

  5. The Aggregation of αB-Crystallin under Crowding Conditions Is Prevented by αA-Crystallin: Implications for α-Crystallin Stability and Lens
    Grosas, A. B., Rekas, A., Mata, J. P., Thorn, D. C. & Carver, J. A.
    Journal of Molecular Biology.

  6. NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide–dithiol oxidoreductase enzyme DsbA
    from Burkholderia pseudomallei
    Nebl, S., Alwan, W. S., Williams, M. L., Sharma, G., Taylor, A., Doak, B. C., Wilde, K. L., McMahon, R. M., Halili, M. A., Martin, J. L., Capuano, B., Fenwick, R. B., Mohanty, B. & Scanlon, M. J.
    Journal of Biomolecular NMR.

  7. Lipoprotein ability to exchange and remove lipids from model membranes as a function of fatty acid saturation and presence of cholesterol.
    Waldie, S., Sebastiani, F., Browning, K., Maric, S., Lind, T. K., Yepuri, N., Darwish, T. A., Moulin, M., Strohmeier, G., Pichler, H., Skoda, M. W. A., Maestro, A., Haertlein, M., Forsyth, V. T., Bengtsson, E., Malmsten, M. & Cárdenas, M.
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1865, 158769.

  8. Decagram Scale Production of Deuterated Mineral Oil and Polydecene as Solvents for Polymer Studies in Neutron Scattering.
    Klenner, M. A., Cagnes, M., Wood, K., Mita, K., Mishimoto, M., Darwish, T.
    Polymer Chemistry.

  9. The Location of the Antimicrobial Peptide Maculatin 1.1 in Model Bacterial Membranes.
    Le Brun, A. P., Zhu, S., Sani, M.-A. & Separovic, F.
    Frontiers in Chemistry, 8.

  10. Spontaneous Self-Assembly of Thermoresponsive Vesicles Using a Zwitterionic and an Anionic Surfactant.
    T. McCoy, J. Marlow, A. Armstrong, A. Clulow, C. Garvey, M. Manohar, T. Darwish, B. Boyd, A. Routh, R. Tabor.

  11. Labeled Rhenium Complexes: Radiofluorination, α-MSH Cyclization, and Deuterium Substitutions.
    Klenner, M. A., Darwish, T., Fraser, B., Massi, M., Pascali, G.

  12. Perdeuterated conjugated polymers for ultralow‐frequency magnetic resonance of OLEDs.
    Lupton, J., Milster, S., Bange, S., Kurrman, S., Kraus, H., Stotzfus, D., Burn, P., Leung, A., Darwish, T., Boehme, C.
    Angewandte Chemie International Edition, 59 (24), 9388-9392.

  13. The antimicrobial peptide maculatin self assembles in parallel to form a pore in phospholipid bilayers.

  14. Sani, M.-A., Le Brun, A. P. & Separovic, F.
    Biochimica et Biophysica Acta (BBA) - Biomembranes, 1862, 183204.

  15. Perdeuteration of poly[2-methoxy-5-(2′-ethylhexyloxy)-1,4-phenylenevinylene] (d-MEH-PPV): control of microscopic charge-carrier spin–spin coupling and of magnetic-field effects in optoelectronic devices.
    Stoltzfus, D. M., Joshi, G., Popli, H., Jamali, S., Kavand, M., Milster, S., Grünbaum, T., Bange, S., Nahlawi, A., Teferi, M. Y., Atwood, S. I., Leung, A. E., Darwish, T. A., Malissa, H., Burn, P. L., Lupton, J. M. & Boehme, C.
    Journal of Materials Chemistry C.


  1. Monitoring the phase evolution in LiCoO2 electrodes during battery cycles using in-situ neutron diffraction technique.
    Jena, A., Lee, P.-H., Pang, W. K., Hsiao, K.-C., Peterson, V. K., Darwish, T., Yepuri, N., Wu, S.-H., Chang, H. & Liu, R.-S.
    Journal of the Chinese Chemical Society, 67 (3), 344-352.
  2. Evolution of structural dimensions in mesoporous template precursor from hexagonal lyotropic liquid crystals.
    Wang, G., Garvey, C. J., Zhang, J., LA, O. D., Krause-Heuer, A. M., Forsyth, M., Darwish, T., Steinhart, M. & Kong, L.
    J Phys Condens Matter, 32, 7.
  3. Potential of neutron powder diffraction for the study of solid triacylglycerols.
    Maynard-Casely, H. E., Booth, N., Leung, A. E., Stuart, B. H. & Thomas, P. S.
    Food Structure, 22, 100124.
  4. PEGylation and surface functionalization of liposomes containing drug nanocrystals for cell-targeted delivery.
    Xiao, Y., Liu, Q., Clulow, A. J., Li, T., Manohar, M., Gilbert, E. P., de Campo, L., Hawley, A. & Boyd, B. J.
    Colloids and Surfaces B: Biointerfaces, 182, 110362.
  5. Conformational selection of the intrinsically disordered plant stress protein COR15A in response to solution osmolarity – an X-ray and light
    scattering study
    Shou, K., Bremer, A., Rindfleisch, T., Knox-Brown, P., Hirai, M., Rekas, A., Garvey, C. J., Hincha, D. K., Stadler, A. M. & Thalhammer, A.
    Physical Chemistry Chemical Physics, 21, 18727-18740.
  6. Controlled deuterium labelling of imidazolium ionic liquids to probe the fine structure of the electrical double layer using neutron reflectometry.
    Akutsu-Suyama, K., Cagnes, M., Tamura, K., Kanaya, T. & Darwish, T. A.
    Physical Chemistry Chemical Physics, 21, 17512-17516.
  7. Multi-dimensional characterization of mixed ligand nanoparticles using small angle neutron scattering
    Luo, Z., Yang, Y., Radulescu, A., Kohlbrecher, J., Darwish, T. A., Ong, Q. K., Guldin, S. & Stellacci, F.
    Chemistry of Materials, 31, 6750-6758.
  8. A Protein-Eye View of the In Meso Crystallization Mechanism
    van 't Hag, L., de Campo, L., Tran, N., Sokolova, A., Trenker, R., Call, M. E., Call, M. J., Garvey, C. J., Leung, A. E., Darwish, T. A., Krause-Heuer, A. M.,
    Knott, R., Meikle, T., Drummond, C. J., Mezzenga, R. & Conn, C. E.
    Langmuir, 35, 8344-8356.
  9. Neutron diffraction of deuterated tripalmitin and the influence of shear on its crystallisation
    Stuart, B. H., Maynard-Casely, H. E., Booth, N., Leung, A. E. & Thomas, P. S.
    Chemistry and Physics of Lipids, 221, 108-113.
  10. Protein Perdeuteration for Neutron Crystallography.
    Duff, A. P.
    Proceedings of the 3rd International Symposium of Quantum Beam Science at Ibaraki University "Quantum Beam Science in Biology and Soft
    Materials (ISQBSS2018)".
  11. A rapid MS/MS method to assess the deuterium kinetic isotope effect and associated improvement in the metabolic stability of deuterated biological and pharmacological molecules as applied to an imaging agent
    Murphy, R. B., Wyatt, N. A., Fraser, B. H., Yepuri, N. R., Holden, P. J., Wotherspoon, A. T. L. & Darwish, T. A.
    Analytica Chimica Acta, 1064, 65-70.
  12. Effect of deuteration on the phase behaviour and structure of lamellar phases of phosphatidylcholines – Deuterated lipids as proxies for the physical properties of native bilayers
    Bryant, G., Taylor, M. B., Darwish, T. A., Krause-Heuer, A. M., Kent, B., Garvey, C. J.
    Colloids and Surfaces B: Biointerfaces, 177, 196-203.
  13. The effects of small molecule organic additives on the self-assembly and rheology of betaine wormlike micellar fluids
    McCoy, T. M., King, J. P., Moore, J. E., Kelleppan, V. T., Sokolova, A. V., de Campo, L., Manohar, M., Darwish, T. A. & Tabor, R. F.
    Journal of Colloid and Interface Science, 534, 518-532.
  14. Studying Munc18:syntaxin interactions using small-angle scattering
    Whitten, A. E., Jarrott, R. J., Hu, S. H., Duff, A. P., King, G. J., Martin, J. L. & Christie, M. P.

    Methods in Molecular Biology.
  15. Deuterated phytantriol – A versatile compound for probing material distribution in liquid crystalline lipid phases using neutron scattering
    ​​​​​Yepuri, N. R., Clulow, A. J., Prentice, R. N., Gilbert, E. P., Hawley, A., Rizwan, S. B., Boyd, B. J. & Darwish, T. A.
    Journal of Colloid and Interface Science, 534, 399-407.


  1. Small-angle neutron scattering studies on the AMPA receptor GluA2 in the resting, AMPA-bound and GYKI-53655-bound states.
    Larsen, A. H., Dorosz, J., Thorsen, T. S., Johansen, N. T., Darwish, T., Midtgaard, S. R., Arleth, L. & Kastrup, J. S.

    IUCrJ, 5, 780-793.
  2. Ionic Liquid Adsorption at the Silica-Oil Interface Revealed by Neutron Reflectometry.
    Cooper, P. K., Li, H., Yepuri, N. R., Nelson, A., Webber, G. B., Le Brun, A. P., Darwish, T. A., Warr, G. G. & Atkin, R.
    Journal of Physical Chemistry C, 122, 24077-24084.
  3. Mass spectrometry and Monte Carlo method mapping of nanoparticle ligand shell morphology.
    Luo, Z., Zhao, Y., Darwish, T., Wang, Y., Hou, J. & Stellacci, F.

    Nature Communications, 9, 4478.
  4. Annexin V-containing cubosomes for targeted early detection of apoptosis in degenerative retinal tissue.
    Ding, Y., Chow, S. H., Liu, G.-S., Wang, B., Lin, T.-W., Hsu, H.-Y., Duff, A. P., Le Brun, A. P. & Shen, H.-H.
    Journal of Materials Chemistry B.
  5. Cellulose Dissolution in Ionic Liquid: Ion Binding Revealed by Neutron Scattering.
    Raghuwanshi, V. S., Cohen, Y., Garnier, G., Garvey, C. J., Russell, R. A., Darwish, T. & Garnier, G.

    Macromolecules, 51, 7649-7655.
  6. BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state.
    Rath, E. M., Cheng, Y. Y., Pinese, M., Sarun, K. H., Hudson, A. L., Weir, C., Wang, Y. D., Håkansson, A. P., Howell, V. M., Liu, G. J., Reid, G., Knott, R. B., Duff, A. P. & Bret Church, W.

    PLoS ONE, 13, e0203003.
  7. Discovery of fragments that target key interactions in the signal recognition particle (SRP) as potential leads for a new class of antibiotics.
    Faoro, C., Wilkinson-White, L., Kwan, A. H. & Ataide, S. F.
    PLoS ONE, 13, e0200387.
  8. Comparing Surfactant Structures at “Soft” and “Hard” Hydrophobic Materials: Not All Interfaces Are Equivalent.
    Wei, Z., Piantavigna, S., Holt, S. A., Nelson, A., Spicer, P. T. & Prescott, S. W.

    Langmuir, 34, 9141-9152.
  9. Solution structure analysis of the periplasmic region of bacterial flagellar motor stators by small angle X-ray scattering.
    Liew, C. W., Hynson, R. M., Ganuelas, L. A., Shah-Mohammadi, N., Duff, A. P., Kojima, S., Homma, M. & Lee, L. K. 
    Biochem Biophys Res Commun, 495, 1614-1619. 
  10. Transient antibody-antigen interactions mediate the strain-specific recognition of a conserved malaria epitope.
    Krishnarjuna, B., Sugiki, T., Morales, R. A. V., Seow, J., Fujiwara, T., Wilde, K. L., Norton, R. S. & MacRaild, C. A. 
    Communications Biology, 1, 58. 
  11. Carbon nanotube mediated miscibility of polyhydroxyalkanoate blends and chemical imaging using deuterium-labelled poly(3-hydroxyoctanoate).
    Russell, R. A., Foster, L. J. R. & Holden, P. J. 
    European Polymer Journal, 105, 150-157. 
  12. Measuring the excitations in a new S = 1/2 quantum spin chain material with competing interactions.
    Rule, K. C., Mole, R. A., Zanardo, J., Krause-Heuer, A., Darwish, T., Lerch, M. & Yu, D. 
    Journal of Physics Condensed Matter, 30, 215602.
  13. Dimensions and Global Twist of Single-Layer DNA Origami Measured by Small-Angle X-ray Scattering
    Baker, M. A. B., Tuckwell, A. J., Berengut, J. F., Bath, J., Benn, F., Duff, A. P., Whitten, A. E., Dunn, K. E., Hynson, R. M., Turberfield, A. J. & Lee, L. K. 
    ACS Nano, 12, 5791-5799. 
  14. Disulfide isomerase activity of the dynamic, trimeric Proteus mirabilis ScsC protein is primed by the tandem immunoglobulin-fold domain of ScsB
    Furlong, E. J., Choudhury, H. G., Kurth, F., Duff, A. P., Whitten, A. E. & Martin, J. L. 
    Journal of Biological Chemistry, 293, 5793-5805. 
  15. Quantitative 3D determination of self-assembled structures on nanoparticles using small angle neutron scattering.
    Luo, Z., Marson, D., Ong, Q. K., Loiudice, A., Kohlbrecher, J., Radulescu, A., Krause-Heuer, A., Darwish, T., Balog, S., Buonsanti, R., Svergun, D. I., Posocco, P. & Stellacci, F. 
    Nature Communications, 9, 1343. 
  16. Penetration behavior of an ionic liquid in thin-layer silica coating: Ionic liquid deuteration and neutron reflectivity analysis.
    Akutsu, K., Cagnes, M., Niizeki, T., Hasegawa, Y. & Darwish, T. A. 
    Physica B: Condensed Matter, 551, 262-265. 
  17. Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance.
    Han, M. L., Velkov, T., Zhu, Y., Roberts, K. D., Le Brun, A. P., Chow, S. H., Gutu, A. D., Moskowitz, S. M., Shen, H. H. & Li, J.
    ACS Chemical Biology, 13, 121-130.

  18. Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering.
    Midtgaard, S. R., Darwish, T. A., Pedersen, M. C., Huda, P., Larsen, A. H., Jensen, G. V., Kynde, S. A. R., Skar-Gislinge, N., Nielsen, A. J. Z., Olesen, C., Blaise, M., Dorosz, J. J., Thorsen, T. S., Venskutonytė, R., Krintel, C., Møller, J. V., Frielinghaus, H., Gilbert, E. P., Martel, A., Kastrup, J. S., Jensen, P. E., Nissen, P. & Arleth, L. 
    FEBS Journal, 285, 357-371. 

Papers resulting from the Australian Centre for Neutron Scattering user program which utilised the National Deuteration Facility (2011-present)