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Chemical deuteration instrument laboratory
National Deuteration Facility

News and highlights

  • Disordered protein

    In the push and pull of crowds, disordered proteins dance precariously

     

    intrinsically disordered proteins (IDPs) carry out a range of important biological tasks and play a key role in several biological functions. In collaboration scientists from RMIT and the CSIRO, research facilitated at the Australian Centre for Neutron Scattering and the National Deuteration Facility reveals how IDPs and their regions behave under various physiological processes.

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  • chemical structure of deuterated ionic liquids

    Deuterated ionic liquids

     

    The favourable properties of ionic liquids make them useful for numerous applications.

    High stability means ionic liquids are suitable for use as electrolytes in extreme environments such as space. The NDF have produced several selectively deuterated ionic liquids that have been used to increase our understanding of ionic liquids.

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  • cytochrome p450 steroid binding

    Studying enzyme mechanisms using deuterated substrates

     

    The NDF is providing deuterated substrates to enable researchers to study enzyme binding. This is important for designing enzymes for applications as drug targets and as biocatalysts.

    These studies demonstrate the broadening user base for the National Deuteration Facility, with requests to synthesise deuterated molecules for neutron as well as non-neutron based applications.

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  • Large book with sticky notes inserted on numerous pages

    2022 Product Catalogue released

     

    The National Deuteration Facility have released the 2022 Product Catalogue, click the link below to download.

  • JACS journal cover

    Insight into membrane fusion in COVID infection

     

    ANSTO’s National Deuteration Facility has provided deuterated cholesterol for international research to gain a better understanding of how the Spike protein of the COVID virus, SARS-Co-V-2, infects human cells through a membrane fusion mechanism.

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  • Michael Moir in chemistry lab with chemical structure of deuterated linoleic acid

    Deuterated linoleic acid-d31: Available now

     

    The NDF has achieved a concise and scalable synthesis to access gram quantities of linoleic acid-d31. The NDF’s expertise in phospholipid synthesis means that desirable linoleoyl lipids can now be synthesised on request.

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  • A gloved hand holding a red capsule

    New type of nanoparticles for drug delivery

     

    Monash University researchers have used advanced techniques at ANSTO to investigate the production of new, elongated polymer nanocapsules with a high payload of drug nanocrystals to potentially increase drug targetability, and also decrease dosage frequency and side effects.

    Read more
  • cell surface

    Supporting new areas of COVID research

     

    ANSTO’s National Deuteration Facility has been providing high-quality deuterated lipids used in the construction of cell membrane models to support research that improves our understanding of how the virus interacts with elements of the cell membrane, a relatively new area of investigation.

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  • Contrast matching mineral oil

    Enabling polymer research

     

    The National Deuteration Facility has supported industry through the synthesis of deuterated mineral oil, which was supplied to Japanese chemical manufacturer Mitsui Chemicals.

    Mitsui Chemicals specialises in polymeric materials for packaging, appliances, construction and other applications. 

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  • Shelves filled with files

    News archive

     

    To access past NDF News and Highlights, please access the page below.

    News archive

Acknowledgements

The National Deuteration Facility is partly supported by the National Collaborative Research Infrastructure Strategy – an initiative of the Australian Government.

NCRIS version 2