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ANSTO welcomes federal funding announcement to support research infrastructure and expertise
ANSTO’s National Deuteration Facility (NDF) is excited to announce it has been granted $2.8 million in National Collaborative Research Infrastructure Strategy (NCRIS) 2023 phase 2 funding from the Australian Government for expansion of existing capabilities and development of new capabilities.
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Successful ARC Discovery Project 2024
NDF researcher Dr Anthony Duff is a partner investigator on a recently awarded 2024 ARC Discovery Project grant valued at $624,710 entitled "The geometry of genome access: lessons from HIV".
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Deuterated squalene and sterols from modified yeast
The National Deuteration Facility at ANSTO continues to support biomedical research on COVID-19 by providing bespoke deuterated lipids for studies of the structure of the virus and its complex molecular interactions.
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NDF staff co-author book chapter on deuteration for biological small angle neutron scattering
Staff from the National Deuteration Facility have co-authored a book chapter featured in “Methods in Enzymology; Small Angle Scattering Part A: Methods for Structural Investigation”.
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Deuteration continues to be an important characterisation tool in understanding COVID infectivity and severity
The National Deuteration Facility at ANSTO continues to support biomedical research on COVID-19 by providing bespoke deuterated lipids for studies of the structure of the virus and its complex molecular interactions.
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In the push and pull of crowds, disordered proteins dance precariously
intrinsically disordered proteins (IDPs) carry out a range of important biological tasks and play a key role in several biological functions. In collaboration scientists from RMIT and the CSIRO, research facilitated at the Australian Centre for Neutron Scattering and the National Deuteration Facility reveals how IDPs and their regions behave under various physiological processes.
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Deuterated ionic liquids
The favourable properties of ionic liquids make them useful for numerous applications.
High stability means ionic liquids are suitable for use as electrolytes in extreme environments such as space. The NDF have produced several selectively deuterated ionic liquids that have been used to increase our understanding of ionic liquids.
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Studying enzyme mechanisms using deuterated substrates
The NDF is providing deuterated substrates to enable researchers to study enzyme binding. This is important for designing enzymes for applications as drug targets and as biocatalysts.
These studies demonstrate the broadening user base for the National Deuteration Facility, with requests to synthesise deuterated molecules for neutron as well as non-neutron based applications.
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Insight into membrane fusion in COVID infection
ANSTO’s National Deuteration Facility has provided deuterated cholesterol for international research to gain a better understanding of how the Spike protein of the COVID virus, SARS-Co-V-2, infects human cells through a membrane fusion mechanism.
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Acknowledgements
The National Deuteration Facility is partly supported by the National Collaborative Research Infrastructure Strategy – an initiative of the Australian Government.