Synthetic biology: biology re-imagined
The NDF received additional funding in the National Collaborative Research Infrastructure Strategy (NCRIS) 2023 uplift funding round for stable isotope labelling of synthetic biology products. This is helping to build new synthetic biology capability by establishing the expertise, platforms, and infrastructure needed to develop next-generation biomanufacturing solutions.Find out more
2026 NDF Product Catalogue released
The National Deuteration Facility (NDF) has released their 2026 Product Catalogue, now containing over 300 unique deuterated molecules.
Deuteration supports blood test to help diagnose breast cancer
The National Deuteration Facility has supplied deuterium labelled lipids to quantify lipid biomarkers in a blood test to help diagnose breast cancer.Find out more
Landmark achievement opens pathway for treatment of drug-resistant tuberculosis
ANSTO has contributed to a recent publication in Nature Communications Biology that represents a landmark achievement in structural biology: an understanding of protein regulation mechanisms in the bacterium, Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) a major global health threat.Find out more
New flow chemistry capability saves deuteration time with high yields
The National Deuteration Facility has developed a capability to use a flow chemistry process to increase efficiency, increase production capacity and reduce decomposition in the synthesis of deuterated molecules.Find out more
Enhancing characterisation capabilities at the NDF
The National Deuteration Facility has recently commissioned a new nuclear magnetic resonance (NMR) spectrometer to enhance characterisation capabilities.Find out more
Deuterated Plasmalogens: A New Class of Labelled Lipids from the NDF
The National Deuteration Facility has recently developed a successful synthetic route to access deuterium labelled plasmalogens, which are an important class of lipid for investigating lipid biology and implications for numerous diseases.
Studies in selective microbial deuteration for chiral molecules
This NDF-led study investigated development of potential cost-effective methods for reductive microbial deuteration (utilising yeast strains) to produce crucial chiral building blocks for medicinal and analytical applications with a high degree of isotopic labelling and enantioselectivity.Combining synthetic organic chemistry and microbes to perform enzymatic transformations allowed the enantioselective synthesis of important chiral molecules.
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Manipulating a Thermosalient Crystal Using Selective Deuteration
Dr Alexander Angeloski of the National Deuteration Facility led a study published in JACS that demonstrated deuteration can manipulate the properties of a crystal that converts heat into mechanical motion.
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Acknowledgements
The National Deuteration Facility is partly supported by the National Collaborative Research Infrastructure Strategy – an initiative of the Australian Government.
