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National Deuteration Facility

User access at the National Deuteration Facility

Modes of access

Proposal submissions to the National Deuteration Facility are accepted for access to NDF capabilities for provision of deuterated and multiple isotopically labelled molecules for neutron scattering and other applications.

There are three modes of access available to NDF capabilities – Merit, User Pays/Collaboration and Commercial which are outlined in further detail below.

Merit access proposals are to be submitted via the online ANSTO Research Portal (ARP) at https://portal.ansto.gov.au/ with four proposal types available:

  • Deuteration: merit access proposal for NDF capabilities within a 6-month round. This proposal type is for overseas neutron experiments or for non-neutron applications (e.g. NMR, MS).
  • Deuteration/Neutron: merit access proposal for ACNS instruments and NDF capabilities where deuterated molecule/s are required for the proposed neutron experiments at ACNS.
  • Program – Deuteration: merit access proposal for a program of research of up to 3 years for access to NDF capabilities of biological and/or chemical deuteration or multiple isotopic labelling. This program proposal type is for overseas neutron experiments or non-neutron applications (e.g. NMR, MS).
  • Program – Deuteration/Neutron: Merit access proposal for a program of research of up to 3 years for access to both ACNS instruments and NDF capabilities, where deuterated molecule/s are required for the proposed program of research utilising ACNS neutron instruments.

Note the Deuteration/Neutron proposal type is part of the ANSTO Anonymised Review Trial for rounds 2022-1 and 2022-2. Please refer to the Anonymised Review webpage for further information.

To discuss User Pays/Collaboration or Commercial access modes or for any queries, please contact the NDF via ndf-enquiries@ansto.gov.au

The NDF utilises both Chemical Deuteration and Biodeuteration techniques. An extensive product list is available providing examples of the types of molecules and labelling accessible (refer to the NDF Product Catalogue available for download below).

1. Merit based user access

Access to the NDF is most commonly via merit-based proposals. 

Dates & submission: Calls for applications close in March and September of each year.  NDF staff can assist with the submission process. We welcome enquiries regarding proposals at any time.

Approval & conditions: Proposals are reviewed externally, internally for feasibility/safety and by the NDF Program Advisory Committee (PAC) who provide a ranking based on scientific merit.​​​​​​ The criteria for this mode is that deuterated molecules are to be used for experiments in Australia using Australian Research Infrastructure* (e.g., ACNS neutron instruments, NMR, MS or other facilities). Co-authorship on resultant publication/s is required.

Costs: If successful, you will receive the deuterated molecule at no cost. There may be some cost recovery negotiated for isotopic materials used for multiple-labelling of proteins, where there are high costs or shipping; or when there are a large number/quantity of material/s requested.

Delivery: The time-frame for delivery of the materials is via negotiation, however, proposals are usually submitted for commencement in the next 6 month block (i.e. March submission for July commencement, September for January commencement).

* Similar approval conditions apply for New Zealand users – please contact NDF to discuss further.

2. User pays/collaboration mode of access

Dates & submission: Proposals for this access mode can be submitted via the 6-monthly merit access rounds (closing mid-March and mid-September) or at any time after discussion with the NDF.

Approval & conditions: Proposals are required to be submitted via the online portal for assessment. Co-authorship on resulting publication/s is also expected for this access mode.

Costs: Under the User Pays/Collaboration arrangement, there is a 50% cost recovery of materials and labour involved. Proposals can be from applicants in both Australia and overseas.

Delivery: dates are by negotiation.

3. Commercial access

Dates & submission: Enquires accepted at any time. NDF will internally manage any proposal submission under this mode.

Approval & conditions: Approval is by NDF Leader discretion. NDF acknowledgement on any resultant publication/s is requested. Minimum quantities for supply of molecules apply.

Costs: Full cost recovery.

Delivery: dates by negotiation.

Certificate of Analysis/Product Data Sheet

For successful proposals, NDF will synthesise and provide the requested deuterated molecules or materials, provide chemical and biological advice and provide the appropriate analyses for the produced deuterated product (e.g., certificate of analysis or product data sheet). Figures/experimental data will also be provided for manuscripts where co-authorship has been negotiated.

Acknowledgement

The National Deuteration Facility is partly supported by the National Collaborative Research Infrastructure Strategy – an initiative of the Australian Government.

NCRIS version 2