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Ryan Middleton

Dr Ryan Middleton

Molecular Biologist / Research Program Manager

Role at ANSTO

Dr Ryan Middleton is a molecular biologist working within the Human Health Research theme at ANSTO. His research interests include understanding the role of the Translocator protein (TSPO) in disease states and improving the clinical response to radiotherapy. 

His role includes managing a program of researchers that are aiming to understand the impact of radiation in order to mitigate the detrimental effects, whilst other projects are looking to optimise radiotherapy. Finally, we utilise nuclear based tools and capabilities to increase our understanding of disease causation and progression.

Currently, Ryan leads research into improving radiotherapy outcomes by examining the infiltration of immune cells into the tumour microenvironment following Synchrotron Microbeam Radiation Therapy. In collaboration with St George Hospital and the Microbiome Research Centre, we are also establishing a project on head and neck cancer to examine the role that the microbiome plays in the development of disease and the response to radiotherapy.  


Molecular cloning, polymerase chain reaction, RNA interference, animal genetics, gene expression, cellular assays, small animal studies

Qualifications & Achievements

  • Winner of the George Collins Award for Innovation, NCEPT team member - ANSTO (2018)
  • Post-Doctoral Researcher - ANSTO (2009-2013)
  • PhD - Johnson and Johnson Research and the University of Sydney (2008)
  • Bachelor of Science in Agriculture, First Class Honours (Dean’s List) - University of Sydney (2002)